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Description
Collagen IV Recombinant Rabbit mAb (SDT-150-5)Product Specification Host Rabbit Antigen Collagen IV Synonyms Collagen type IV (CIV) Immunogen Recombinant Protein Location N A Accession P02462 Clone Number SDT 150 5 Antibody Type Recombinant mAb Application Sandwich ELISA Reactivity Human Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8
Product Specification
| Host | Rabbit |
| Antigen | Collagen IV |
| Synonyms | Collagen type IV (CIV) |
| Immunogen | Recombinant Protein |
| Location | N/A |
| Accession | P02462 |
| Clone Number | SDT-150-5 |
| Antibody Type | Recombinant mAb |
| Application | Sandwich ELISA |
| Reactivity | Human |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Background
Type IV collagen is a type of collagen that is responsible for providing a scaffold for stability and assembly. It is also predominantly found in extracellular basement membranes. It aids in cell adhesion, migration, survival, expansion, and differentiation. After secretion into the extracellular membrane, these molecules will further interact to form higher molecular organizations. These, along with other proteins, will form unique basement membranes in tissue-specific manners. Through interactions with specific cellular receptors such as integrins, the basement membrane collagen IV networks not only provide structural support to the cells and tissues, but they also affect the biological rate during and after the development. New discoveries keep unraveling information about genetic mutations, biosynthesis, molecular assembly, and network formation of type IV collagen, and this increases the understanding of the critical role of this collagen in health and disease.Liver fibrosis and cirrhosis are associated with the deposition of collagen IV in the liver. Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease and hepatitis C and fall following successful therapy.
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