SKU: 4566122984

S23 – Solution, 600MG (20mg/mL)

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Description

S23 – Solution, 600MG (20mg/mL)S23 S23 is an orally available selective androgen receptor modulator (SARM). Originally developed by GTX Inc. as a form of hormonal contraception for men, it exhibits a high affinity for the androgen receptor, with a Ki value of 1. 7 nM. A study published by Jones et al. compared the effectiveness of S23 in both castrated and intact male rats. Effects of S23 on Fertility In castrated male rats, the effective dose of S23 in the prostate was 0. 43 mg

S23

S23 is an orally available selective androgen receptor modulator (SARM). Originally developed by GTX Inc. as a form of hormonal contraception for men, it exhibits a high affinity for the androgen receptor, with a Ki value of 1.7 nM. A study published by Jones et al. compared the effectiveness of S23 in both castrated and intact male rats.

Effects of S23 on Fertility

In castrated male rats, the effective dose of S23 in the prostate was 0.43 mg/day, and 0.079 mg/day in the levator ani muscle. In intact male rats, a dose higher than 0.1 mg/day resulted in a suppression of luteinizing hormone (LH) by more than 50%. This dose corresponded with a reduction in prostate size and an increase in the size of the levator ani muscle.

In a study involving intact male rats subjects treated with both S23 and estradiol benzoate (to maintain sexual behavior), no sperm was found in the testes of four out of the six subjects after 10 weeks. Moreover, none of the six subjects reported a pregnancy. Following treatment, infertility was completely reversible; all subsequent mating trials resulted in pregnancy.

Effects of S23 on Muscle Mass and Body Fat

S23 exhibits effects on muscle mass and body fat that are similar to those of anabolic steroids. Research involving male rats revealed that treatment with S23 led to a reduction in total body weight and fat mass. Rats in this study were also administered estradiol benzoate to maintain sexual behavior. Despite the known muscle loss effects of estrogens, the combination with S23 neutralized this effect, resulting in an increase in muscle mass in the male rats.

Additionally, another study indicated that S23 might be effective against muscle loss caused by prolonged use of glucocorticoids. This research also looked at the effects of S23 on muscle atrophy induced by castration. In both scenarios, muscle loss was observed, but the administration of S23 and testosterone blocked the dexamethasone-induced dephosphorylation of Akt. The findings suggest that S23 could be an effective treatment against muscle loss induced by glucocorticoids.


concentration
20mg/ml.

half-life
12 hours

DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary use. Please use with our DISCLAIMER before ordering.

 

Data sheet

S-23 – Solution, 600mg (20mg/mL)

Application Selective Androgen Receptor Modulator
CAS 1010396-29-8
Molar Mass 416.753 g/mol
Chemical Formula C18H13ClF4N2O3
IUPAC Name (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide
Synonyms UNII-XDK89456WM, 3-(4-cyanophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide, CCTH-methylpropionamide
Storage Room Temperature
Solubility Soluble in PEG400, Ethanol
Organoleptic Profile Clear liquid
Physical Form Solution in PEG400
Specification 20mg/mL ±5%
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our disclaimer prior to ordering.
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SKU: 4566122984

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Reviewed in the United States on January 29, 2026
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★★★★★ 4
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Reviewed in the United States on March 18, 2026
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Massapequa, US
★★★★★ 5
Fixed noisy and leaking power steering pump
My daughters 2008 Honda Accord 2.4L 4 cylinder that had a very noisy power steering pump which was also starting to leak. I was about to buy a new pump when I found out it might just be leaking from the hoses to the pump. I bought these O rings for the hose connections at the power steering pump, and spent 15 minutes replacing them. Pump is quiet again! The suction hose can develop a leak, letting air get into the pump which creates the loud noises. This fix is all I needed, and was much cheaper and faster than replacing the power steering pump.
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