SKU: 54669563742

SAMe (Designs for Health), 30 capsules

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Description

SAMe (Designs for Health), 30 capsulesDownload Patient Handout SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. It is the most active of all methyl donors and has been compared to ATP in its importance for the body. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate. SAMe is involved in the synthesis of neurotransmitters, the hormone melatonin, phospholipids, and

Download Patient Handout

SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. It is the most active of all methyl donors and has been compared to ATP in its importance for the body. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate.

SAMe is involved in the synthesis of neurotransmitters, the hormone melatonin, phospholipids, and polyamines, which control cellular growth. It is also the source of methyl groups inside the nucleus for DNA methylation, which controls gene expression and masking of genetic damage.

These capsules provide 200 mg of SAMe along with vitamins B6, B12, and folate as 5-MTHF in order to provide cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine.

As a dietary supplement, take one capsule per day, preferably on an empty stomach, or as directed by your health care practitioner.

Serving Size: One Capsule

Amount Per Serving
Vitamin B-6 ... 5mg
(as Pyridoxal-5-Phosphate)
Folate ... 170mcg DFE
(as Quatrefolic® [6S]-5-Methyltetrahydrofolate, glucosamine salt 200mcg)
Vitamin B-12 ... 50mcg
(as Methylcobalamin)
SAMe ... 200mg
(as S-Adenosyl-L-Methionine Disulfate P-Toluensulfate)

Other Ingredients: Cellulose (capsule), microcrystalline cellulose, vegetable stearate, calcium chloride anhydrous, calcium oxide.

This product does not contain gluten.

Quatrefolic® is covered by U.S. Patent No. 7, 947, 662 and is a registered trademark of Gnosis S.p.A.

NOTICE
Color, size or shape may appear different between lots.

Store at room temperature. Keep out of reach of children.

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent disease.

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SKU: 54669563742

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Brooklyn
Birmingham, US
★★★★★ 5
Dogs favorite toy
Color: Orange & Blue Roller, Size: 7.5 inches (1 Pack), Color: Orange & Blue Roller, Size: 7.5 inches (1 Pack)
I buy 4 of these every month for my dog. He won’t go anywhere without this ball. He sleeps with it, swims with it, goes to the vet and carries it around in his mouth to show off. It’s borderline a problem. My dog is a large breed and plays hard so I do purchase often because the strings unravel and the ball itself is foam so breaks down into little pieces after a few days of playing. I love that it is fragile on his teeth and jaw. We can play catch indoors because it is soft.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 24, 2026
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NATTY
Lexington, US
★★★★★ 5
Love It!
Color: Orange & Blue Fetch Ball, Size: 4.75 inches (1 Pack)
Perfect for your dog who loves to play ball indoors. It doesn’t bounce & it’s very soft. It lasted a long time for a German Shepherd who loveeess to ball all day.
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Reviewed in the United States on June 10, 2026
S
Verified Purchase
susan schwartz
Grantham, US
★★★★★ 5
Just what we needed
Color: Orange & Blue Squirrel, Size: 4.7 inches (1 Pack)
This toy has been great for my dog who eats all her toys! We were having such an issue with all of her toys being so hard that we didn’t want to throw them around our house. This was the perfect solution. She hadn’t eaten through it and it’s nice and soft for fetch without destroying your house!
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Reviewed in the United States on June 3, 2026
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Megan
Lexington, US
★★★★★ 4
My lab loves t
Color: Orange & Blue Fumbler, Size: 3 x 8.5 x 9 inches (1 Pack)
This toy is my labs favorite toy. She’s obsessed and we were happy to find a toy she loves that can stay inside with us. The problem is how easily she tears it apart. We have to buy her a new one every month because when she bites into it it breaks down the foam inside, and from there she shreds the roping it’s covered in. We try to stop her, but with how often we play with it it’s inevitable. We have resigned ourselves to buying a new one once a month.
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Reviewed in the United States on April 7, 2026
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Heather E.
Battle Creek, US
★★★★★ 5
Worth the purchase
Color: Orange & Blue Fumbler, Size: 3 x 8.5 x 9 inches (1 Pack)
Perfect for indoor use. My aggressive chewer loves this and has not destroyed it yet after 6 months. I recommend for indoor use as it causes NO damage or noise.
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Reviewed in the United States on May 24, 2026

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