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Description
GW-0742 Solution, 600MG (20mg/mL)GW 0742 GW 0742 functions as a dual PPAR agonist and antagonist, with its specific action depending on the dosage administered. Additionally, it demonstrates low level activity on various nuclear receptors. It has been identified as an antagonist for both androgen receptors and Vitamin D Receptors (VDR). Computational (in silico) modeling indicates that GW 0742 may also exert influence on thyroid hormone receptors. Multiple studies suggest that GW
GW-0742
GW-0742 functions as a dual PPAR-β agonist and antagonist, with its specific action depending on the dosage administered. Additionally, it demonstrates low-level activity on various nuclear receptors.
It has been identified as an antagonist for both androgen receptors and Vitamin D Receptors (VDR). Computational (in silico) modeling indicates that GW-0742 may also exert influence on thyroid hormone receptors.
Multiple studies suggest that GW-0742 can ameliorate experimentally-induced pancreatitis in mice. It has further been shown to mitigate hypertension in diet-induced obese mice. Currently, it is under investigation as a prospective antidiabetic agent and has demonstrated anti-inflammatory effects.
Concentration
20 mg/ml
Half-Life
24 hours
Disclaimer
This substance is exclusively available for laboratory research purposes. Sale terms and conditions apply. It is not intended for human consumption, or for use in medical, veterinary, or household applications. Please consult our disclaimer prior to making a purchase.
Included is a precision pipette marked per 0.2 ml!
Shake well before use.
Data sheet
GW-0742 – Solution, 600mg (20mg/mL)
| Application | Potent PPARβ and PPARδ agonist |
| CAS | 317318-84-6 |
| Molar Mass | 471.5 g/mol |
| Chemical Formula | C21H17F4NO3S2 |
| IUPAC Name | 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid |
| Synonyms | GW0742, 317318-84-6, GW 0742, GW-0742, GW0742X, GW610742, GW-0742X, CHEMBL38508, CHEBI:79991, {4-[({2-[3-Fluoro-4-(Trifluoromethyl)phenyl]-4-Methyl-1,3-Thiazol-5-Yl}methyl)sulfanyl]-2-Methylphenoxy}acetic Acid, SR-05000000447, 3tkm, GW 0742X, GWdelta 0742, GW 610742, GW-610742, DSSTox_CID_20760, DSSTox_RID_79591, DSSTox_GSID_40760, MLS006011159 |
| Storage | Store at room temperature, tightly sealed, away from heat, light and moisture. |
| Solubility | Soluble in DMSO, PEG 400 |
| Organoleptic Profile | Clear liquid |
| Physical Form | Solution in PEG 400 |
| Specification | 20mg/mL ±5% |
| Terms | This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering. |
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4.5 ★★★★★
Based on 7 reviews
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Product Reviews
★★★★★ 5
Large time, date, and day of the week, with indiglo too! But band doesn't hold up.
Color: Pink/Rose Gold-Tone, Color: Pink/Rose Gold-Tone
I am used to keeping my watch on all the time, so always buy “water resistant” ones. This one seems to be holding up well to using in the shower, but time will tell — I’ve only had it a month and a half so far. [My last 3 (one a Casio; two different Timexes) stopped working after a year or two, and either you couldn’t change the battery or it didn't help for long.] It’s not overly big / i.e. feminine enough, yet easy to read with my older eyes. I like the rose gold, fleshy pink color, and the strap works great - no links to remove or stretch to find difficult to get over my fist, and it doesn’t roll so much to my pinky side that I can’t see it when I rotate my wrist to see the time or date (like my last . The indiglo works well too. I’m very happy with it! I will update my review if it doesn’t last long.
Update: I love this watch, as it matches my skin color pretty well (which makes it less obtrusive) and is waterproof. I've gone through two of them now, though. Each only lasted 9 months, but the watches themselves were still working. I was doing chores involved with taking care of my goats, and ripped the area where the watchband attaches to the watch, and unfortunately, that rip keeps the pin from securing. Nevertheless, I might buy one again. My husband says it's the nicest one I've had and is okay with buying a new one every 9 months. Picture of the small rip on the right side.
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Reviewed in the United States on August 12, 2024
★★★★★ 5
Nice Simple Watch
Color: Pink/Rose Gold-Tone, Color: Pink/Rose Gold-Tone
Nice simple watch. Bought it for my 11-year-old daughter so she can keep time while running. Her wrist is 5 inches, and the watch tightens up enough on her wrist for a decent fit. She is able to use the watch easily. Note, no directions on how to set up, but I as able to figure it out. Recommend 5 stars.
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Reviewed in the United States on June 2, 2026
★★★★★ 4
Very good watch
Color: White/Chrome-tone
Was a gift for my girlfriend. I even liked it has a mode for two different times sets.
The strap does get dirty fast. But its really useful this watch and very good in estetics.
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Reviewed in the United States on October 24, 2025
★★★★★ 5
Very nice feminine quality watch
Color: Pink/Rose Gold-Tone, Color: Pink/Rose Gold-Tone
I purchased this watch for work. As a nurse, I need the exact date and time in military time and seconds, so this watch is perfect. It’s the 3rd of this kind that I’ve ordered over the years and this one is definitely my favorite. Much easier to program than previous models and the look is very feminine and cute. Of course being water resistant is important since I have to wash my hands a million times a day. I’m hoping it will last a long time as previous models have. Usually the plastic band breaks from daily wear and tear before the battery has ever stopped, but that’s after years of daily use. That’s why I prefer to stick with this brand. They’ve always been very durable, lightweight, and effective for what I need it for. I would definitely recommend. This version is the cutest, like I would wear it even when not working. So I’m very happy with it.
*** Update:
2 years later I still wear this watch everyday, at work or not. Has never broken, battery still going strong and still so pretty. Awesome 👏🏻
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Reviewed in the United States on June 13, 2024
★★★★★ 5
Great modest, minimalist digital watch: 2 time zones, Indiglo, subtle hourly chime
Color: Purple/Silver-Tone
Great value and this is nice, low-key but functional and sleek timepiece. I bought it to replace an older Ironman (bulkier) watch that finally reached end of life after LOTS of adventures (still functions, but strap and face just really couldn't be taken into corporate or social settings without expectation of some heckling). I REALLY like most of the new features (especially the dual time zones, hourly chime (can toggle on/off), and Indiglo applied to the numbers/text rather than as background), I probably would have switched to this earlier if I had known of them. Slight negative that the hourly chime toggle is nested within the time setting workflow, so can't just nearly instantly switch it when heading into movie/performance/other setting where want to silence it fully. I can't speak to the water resistance of this one yet, have been taking it off to shower and haven't been swimming yet. (Taking it off to shower in part because had seen other reviews noting that the trim around the dial may not be long-lasting. So out of caution to extend its appearance, I'll probably remove it for salt/chlorinated water swims (not timing laps)). Only other aspect should note is that the feature that helps to "lock" the strap band at end (bit of a nub to catch) is bit tricky when putting it on / taking it off, may be even more so for those with arthritis or other condition that would make it extra challenging/frustrating to maneuver and engage.
Quite happy with it overall though, just a slight annoyance when putting on / taking off (which may not apply for most if they just leave it on).
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Reviewed in the United States on January 17, 2023
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