SKU: 86464046556

IBUTAMOREN (MK-677) Powder, 1gr

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Description

IBUTAMOREN (MK-677) Powder, 1grMK 677 is a long acting agonist of the ghrelin receptor and stimulates the production of human growth hormone (GH). This spiroindoline sulfonamide is also known as Ibutamoren, MK 677, L 163,191 and was formerly referred to as Oratrope. In a study conducted by Jacks et al., published in Endocrinology in 1997, 8 beagles were administered doses of MK 677 of 0. 25 mg kg. This resulted in GH levels being 5. 3 times higher than the original baseline levels.

MK-677 is a long-acting agonist of the ghrelin receptor and stimulates the production of human growth hormone (GH). This spiroindoline sulfonamide is also known as Ibutamoren, MK-677, L-163,191 and was formerly referred to as Oratrope.

In a study conducted by Jacks et al., published in Endocrinology in 1997, 8 beagles were administered doses of MK-677 of 0.25 mg/kg. This resulted in GH levels being 5.3 times higher than the original baseline levels. At a dose of 0.5 mg/kg, GH levels increased 9 times, and at a dose of 1 mg/kg, they increased almost 16 times (15.8 times the baseline value). It's important to emphasize that these doses were administered orally, rather than via intravenous or intramuscular injection.

The insulin-like growth factor remained elevated by 30% for 8 hours, indicating that MK-677 is a long-acting compound, at least in beagles. GH levels also remained elevated for up to 6 hours. The authors of the study noted that cortisol levels also increased but to a lesser extent than GH levels.

MK-677 is not just a GH secretagogue but also an orally active agonist of the ghrelin receptor. This means that it has an effect on ghrelin receptors. Zhang et al. explain that the "hunger hormone" ghrelin activates the ghrelin receptor (GHSR) to stimulate food intake and GH release, as well as to regulate reward signaling.

Besides its role in signaling hunger, it also influences various other physiological processes including stress, glucose metabolism, body weight, cognition, intestinal motility, food craving, adiposity, and even pain perception.

An extensive study by Zhang and his team on the chemical structure of MK-677 showed that this compound mimics the first four N-terminal residues of ghrelin, including the octanoyl group that binds to the lower region of the ligand-binding pocket. More details can be found in their research paper: Link to paper

For more information on the various target organs of ghrelin, see the following image: Link to image

In another study, published in the International Journal of Molecular Sciences, Jeong et al. administered MK-677 to mice genetically predisposed to overproducing amyloid beta-peptide (Aβ). This protein is responsible for the plaques and tangles observed in the brains of Alzheimer's patients. The mice received MK-677 injections for ten days at doses of 0.1, 1, and 3 mg/kg. The last two groups showed increased food intake, especially at the 3 mg/kg dose. However, at the end of the ten days, there was no significant difference in body weight between the different dosage groups.

The study showed that treatment with MK-677 resulted in reduced Aβ deposition, fewer neuronal and synaptic losses, and reduced glial changes in the cortical layers of the brain. Furthermore, the researchers concluded that MK-677 also reduced neuroinflammation and neurodegeneration associated with Aβ.

DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary use. Please use with our DISCLAIMER before ordering.

Data Sheet

MK-677 (Ibutamoren Mesylate) – Powder, 1g

Application A potent, non-peptide ghrelin receptor agonist
CAS 159752-10-0
Molar Mass 528.662 g/mol
 Chemical Formula C27H36N4O5S
IUPAC Name 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid
Synonyms Ibutamoren, MK-677, MK-0677, MK677, L-163,191, L163191, Nutrobal
Storage Minimize open air exposure, store in a cool dry place. This product is hygroscopic. It can absorb moisture from the air and form hard clumps.
Solubility Soluble in Water, Ethanol, PEG400
Organoleptic Profile Beige fine powder, hygroscopic, acrid odor
Physical Form Solid
Specification ≥98%
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
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SKU: 86464046556

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DeannaLea
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★★★★★ 5
These pillows are way nicer than hotel pillows!
Size: Queen / Standard, Color: White
This is a real review and I am not a robot. I’m actually sleeping with these pillows right now. They are so comfortable the right softness levels. Oh my gosh they’re awesome. I don’t know about hotel pillows, but these are way better quality form with your head and you sleep like a baby.
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Reviewed in the United States on May 29, 2026
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Candice
Phoenix, US
★★★★★ 5
Absolutely Amazing!! Truly the perfect pillow!
Size: Queen / Standard, Color: White
I absolutely love these pillows. They couldn't be more perfect! I have spent years buying and throwing out pillow after pillow. I struggle with a lot of neck and upper back pain and I struggled even more trying to find the right pillow on top of spending several hundred dollars on pillows that just got tossed. If you want a great night of sleep and you want to wake up feeling refreshed and not struggling with fatigue and every day neck or back pain you absolutely MUST give these pillows a try!!! They are super easy to wash, made with great quality and have not once bothered my many allergies like most pillows do. I have not noticed any of the chemical odors moat pillows give off, easy to adjust does great with just occasional fluffing. So far has stayed fluffy for me although I did put it in the dryer a time or two as the instructions stated to help with extra fluff and also because I couldn't wait for them to air fluff when they first arrived, an Air B&B we stayed at had these and I ordered them before we even headed back home I loved them so much I had to order my own and was too impatient to wait!
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Reviewed in the United States on May 30, 2026
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Marie Phillips
Waukegan, US
★★★★★ 4
Comfortable Support
Size: King, Color: White
These bed pillows provide good comfort and support for sleeping, with a nice balance of softness and structure. They hold their shape fairly well and work for both back and side sleeping positions. The overall feel is comfortable and helps improve sleep quality. Overall, they are reliable everyday pillows that offer good comfort and support.
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Reviewed in the United States on May 8, 2026
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Legal_Alien
Massapequa, US
★★★★★ 5
Very comfortable. On the soft side.
Size: Queen / Standard, Color: White
Soft, but not too soft. I would actually give 4.5 stars. The pillow is a bit too long and bulky, wish it had a bit more support, but overall, great purchase considering the price. Hopefully it doesn't degrade after washing.
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Reviewed in the United States on May 24, 2026
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Bee-Bee
Lexington, US
★★★★★ 5
Excellent pillows that are worth the cost
Size: Queen / Standard, Color: White
These are wonderful. Completely relieved my back pain the first night I slept on them -– I put one underneath my back as I slept, and a weeklong terrible pain vanished overnight. Felt like sleeping on a cloud. As others have noted, they are neither too soft nor too firm…they’re really just right, and I think would make great guest room pillows since everyone would like them. These were definitely worth the money.
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