NMNR™ Pro Synergy - 90 capsules

Finally, NMN and NR Together

• NMN and NR elevate NAD+ through complementary pathways*^1,2
• Powers cellular energy to support brain, heart, and whole-body vitality*^3-5
• Enhances mitochondrial performance and resilience with age*^3-5
• Includes TMG to support balanced methylation*⁶
• Addresses key drivers of healthy aging*^2,7

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The Next Evolution in NAD+ Science

NMNR™ Pro Synergy unites NMN and NR in one advanced formula designed to restore and sustain cellular NAD+ levels. This dual-precursor approach fuels energy production, supports DNA repair, and promotes cellular revitalization. With added TMG to maintain methylation balance, the formula delivers comprehensive, long-term support for healthy aging and vitality.*^1-7

How It Works

This formula is designed to help restore NAD+ through three complementary mechanisms.

• NMN (Nicotinamide Mononucleotide)
  NMN is an immediate precursor to NAD+ that bypasses early rate-limiting steps in the salvage pathway. It supports rapid increases in intracellular NAD+, helping energize mitochondria and activate sirtuin enzymes involved in cellular repair and longevity.*^3,4
• NR (Nicotinamide Riboside)
  NR complements NMN by supporting systemic NAD+ synthesis through distinct transport and conversion pathways. Hydrogen malate enhances NR bioavailability and provides malic acid, a key component of the Krebs energy cycle.*^2,8
• Trimethylglycine (TMG)
  TMG provides methyl groups needed to recycle homocysteine into methionine, supporting balanced methylation and maintaining NAD+ homeostasis. It also protects against the potential depletion of methyl donors during NAD+ synthesis from NMN and NR.*⁶

Together, these clinically studied ingredients help restore healthy NAD+ levels and strengthen the body’s natural capacity for energy, repair, and resilience.*^1-5

Why NAD+ Matters

Nicotinamide Adenine Dinucleotide (NAD) is a vital coenzyme present in every cell, essential for creating and maintaining energy throughout the body. Each human cell contains hundreds of millions of NAD+ molecules that power metabolism, drive DNA repair, and activate key enzymes like PARPs and sirtuins, which sustain cellular integrity, stress resilience, and healthy aging.^9,10

As we age, NAD+ levels naturally decline. This reduction diminishes mitochondrial energy production and weakens the activity of sirtuins, PARPs, and AMPK, leaving cells more susceptible to damage. The decline is further accelerated by increased CD38 activity — an enzyme that degrades NAD+ and disrupts energy balance.^9,10

Restoring NAD+ levels with precursors such as NMN and NR, complemented by TMG for methylation support, helps sustain cellular energy production and preserve healthy NAD+ metabolism over time.*^6,9,10

What Makes Ours Better?

• Dual-Pathway NAD+ Support: Combines NMN and NR to enhance both intracellular and systemic NAD+ synthesis.*^1,2
• Methylation-Enhanced: Includes 300 mg TMG per serving to maintain methylation balance and support healthy clearance of NAD+ metabolites.*⁶
• Targeted Liver Support: Supplies key nutrients that drive hepatic detoxification and help restore balance.*
• Clinically Supported Dosing: Delivers 1000 mg of NAD+ precursors per serving, reflecting levels used in human studies demonstrating improvements in cellular and metabolic function.*^3-5
• Synergistic Design: Developed to activate multiple longevity mechanisms — from NAD+ synthesis and recycling to sirtuin and AMPK activation.*¹⁰

The ProHealth Difference

• Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts.
• Triple Lab Tested: Verified three times by independent labs for purity and potency.
•  Full Transparency: Third-party test results published online for complete confidence.
• USA Manufactured: Proudly manufactured in the USA in FDA-registered, GMP-certified facilities since 1988.
• 100-Day Risk-Free Guarantee: If you’re not fully satisfied, we’ll refund your purchase in full.

A Word from our Chief Science Officer

"People tend to fall into camp NMN or camp NR. But why not do both? These two forms of vitamin B3 act at different points in the NAD+ pathway, working together to sustain NAD+ levels across multiple tissues. Used in combination, they provide broader support for the entire NAD+ metabolome."

Ingredient Info

Nicotinamide Mononucleotide (NMN): A vitamin B3 derivative and essential precursor in the NAD+ production pathway.*
Nicotinamide Riboside (NR): A vitamin B3 derivative and essential precursor in the NAD+ production pathway.*
Trimethylglycine (TMG): A natural methyl donor that supports NAD+ metabolism and maintains homocysteine balance.*

References:

1. Huang H. Front Aging. 2022;3:851698.
2. Orr ME et al. GeroScience. 2024;46(1):665-682.
3. Kim M et al. Nutrients. 2022;14(4):755.
4. Janssens GE et al. Nat Aging. 2022;2(3):254-263.
5. Nascimento EBM et al. J Clin Endocrinol Metab. 2021;106(5):1437-1447.
6. Arumugam MK et al. Biology. 2021;10(6):456.
7. Yi L et al. GeroScience. 2023;45(1):29-43.
8. Mehmel M et al. Nutrients. 2020;12(6):1616.
9. Radenkovic D et al. Pharmaceuticals (Basel). 2020;13(9):247.
10. López-Otín C et al. Cell. 2023;186(2):243-278.