SKU: 87097093269

Hista Clear - DAO Enzyme (60 tablets)

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Description

Hista Clear - DAO Enzyme (60 tablets)NEW: Now in NEW packaging Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food derived histamine in the digestive tract. Our bodies are complex, and there is usually more at play than we think. What most dont take into consideration when addressing histamine related

NEW: Now in NEW packaging

Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  

Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here!

Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.

 

Clinical Applications
  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*
Description:


Hista Clear provides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*

Discussion:

Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*

Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]

Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]

Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]

Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]

Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*

Read our article: Low Histamine Diet: The High Histamine Foods List

Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.

Video:


Directions:

Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.

Cautions:

Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.


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SKU: 87097093269

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Arty
Chelsea, US
★★★★★ 5
Great suit!
Size: 8, Color: Mint Green, Size: 8, Color: Mint Green
This suit is gorgeous. The color is gorgeous The fit is great. I like pretty much everything about it. I even like the clasp in the bow tie. Way better than the snaps or the hooks… And my son likes it! After telling me he felt embarrassed to wear a suit like two weeks ago, he was actually really liking this one and was trying to think of somewhere he could wear it! *please ignore the straight-out-of-the-package rumpling in the pictures* The fabric is nice. It’s really well made. It still fits a teeny smidge big on my son, but he’ll be in it in no time. It’s a great value. I recommend it.
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Reviewed in the United States on April 19, 2026
B
B
Whiting, US
★★★★★ 3
THESE ARE NOT LINEN - 70%Polyester, 25% Linen, 5% Spandex
Size: 5, Color: Light Grey
Moms be ware this is NOT LINEN! This is 70% Polyester and 25% linen and 5% spandex, so the listing description and material details are misleading. If you're expecting the super soft, lightweight, breathable linen fabric we know and love , this is not it. This is reminicent of those old school curtains. The suit is cute however; but what boys suit isn't cute for that matter? I would say these run a little big. My son who is 5 normally fits a bit snug in a 5 but the length of a 6 is too long. I ordered a 5 and these are long on him, but the suit jacket fits perfectly. They do seem to be sewn well and constructed with quality in mind. I'm just disappointed by the misleading linen claim
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Reviewed in the United States on April 27, 2026
R
Rachel Rose
Alexandria, US
★★★★★ 5
Size down if between sizes, well made, classic design.
This linen suit made the perfect Easter outfit and looked even better in person. The color is beautiful and exactly what was shown online, with a soft, neutral tone that feels classic and elevated. The material is lightweight and breathable, which was great because my toddler stayed comfortable and didn’t get too hot. You can really feel the quality in the fabric, and the stitching is well done with no loose threads. My toddler usually wears a 4T on top and a 3T on the bottom, so I chose a 4T to make sure the jacket fit properly. The shoulders fit great, but the sleeves were a little long. Rolling them gave it a more styled look and fixed the fit easily. The pants were a bit big, so I pinned them for a more tailored fit. If you’re between sizes, sizing down would give a more fitted look overall. He loved the pockets and kept using them, which was such a fun detail. He also said it was comfortable and was genuinely excited to wear it, which says a lot. The whole outfit looks so polished and dashing, and it’s such a great addition to his wardrobe for special occasions.
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Reviewed in the United States on March 28, 2026
P
Prasoon Dhungana
Bozeman, US
★★★★★ 5
Stylish Slim Fit Suit, Great Quality and Budget-Friendly
I absolutely love this slim fit tuxedo suit for kids. The color looks great, the finish is impressive, and it honestly looks way more expensive than it is. I can’t wait for my son to be invited to the next party, wedding, or special event because this outfit is such a classy and adorable choice. The material feels good quality, the stitching is well done, and the overall design is sharp and stylish. It’s a perfect ring bearer outfit and looks very polished in photos. Full disclosure, I intentionally ordered a size up for my toddler, so it doesn’t fit him perfectly right now. But even with that mistake, I can tell the sizing is true to size, so I would recommend ordering your child’s actual size for the best slim fit look. Overall, this is an excellent, budget-friendly suit set that looks amazing and is perfect for special occasions.
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Reviewed in the United States on April 6, 2026
F
F. Wallace
Houston, US
★★★★★ 5
linen suit
I love this linen suit! It runs true to size and made really well. The bowtie is easy to put on and adds the perfect touch of class to an already fancy suit. The material is light and airy on the suit. It wears well and can be worn for a casual outing or something more fancy like a wedding. This was chosen for a wedding on the beach and it captured the beach vibe perfectly. I would highly recommend this for anyone looking for something comfortable yet stylish for their little guy. For the quality of the outfit, this is priced way below my expectation.
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Reviewed in the United States on March 31, 2026

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