SKU: 87097093269

Hista Clear - DAO Enzyme (60 tablets)

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Description

Hista Clear - DAO Enzyme (60 tablets)NEW: Now in NEW packaging Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food derived histamine in the digestive tract. Our bodies are complex, and there is usually more at play than we think. What most dont take into consideration when addressing histamine related

NEW: Now in NEW packaging

Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  

Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here!

Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.

 

Clinical Applications
  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*
Description:


Hista Clear provides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*

Discussion:

Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*

Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]

Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]

Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]

Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]

Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*

Read our article: Low Histamine Diet: The High Histamine Foods List

Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.

Video:


Directions:

Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.

Cautions:

Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.


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SKU: 87097093269

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Cgreen
Natrona Heights, US
★★★★★ 5
Best organizer with a water spout to keep them counter dry!
Color: Black - 9.25″, Color: Black - 9.25″
I am thoroughly impressed with this product. I tried a product that goes over the middle of the sink and it blocked everything off and would always fall off in a funny ways. I had no room for my pots and pans and started getting irritated with it. This is up and out of the way has a little spicket to drain off the water and as you can see I got all of my sponge and soaps in the same spot which is wonderful cleaned off my counter beautifully. I chose the color black to blend in with my black countertop and also to look nice and clean on the counter. One of the best organizers I have ever found for a countertop. It's sturdy metal so far seems rust resistant, but I haven't had it long enough to know for sure. Mobilize easily to clean. Fabulous little sink caddy. I highly recommend to those of you that like to be organized and keep your counter nice and dry, and still arrange things so that it can be out of the way.
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Reviewed in the United States on April 13, 2026
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Wisco Mom
Pawtucket, US
★★★★★ 5
Excellent, all around caddy!
Color: Black - 9.25″
The Cisily Sink Caddy is working out nicely. It holds my sponges, scrubbers and soap bottles. It’s easy to clean and it Excellent all around is well made. I am very happy with my purchase!
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Reviewed in the United States on May 11, 2026
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Yoly
Phoenix, US
★★★★★ 5
No Rust, No Fuss, A simple but great Sink Item
Color: Black - 9.25″
For years I just had my sponges just laying on or around the sink but this year I decided I needed something to hold the soups and cleaning detergent. Along with not being too pricy and that is how I stumbled upon this sink caddy it has worked amazingly. It holds the detergent, sponge, and tube brushes with no problem and any water is drained out from the little spout underneath it. You can adjust the dividers so you can have how you want things separeted from each other and with the bottom being plastic you don't have to worry about getting any rust there. If you need something to make more space around your sink this item will help you.
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Reviewed in the United States on May 27, 2026
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Amazon Customer
Houston, US
★★★★★ 4
Functional neat and worth it!
Color: Navy Blue - 9.25″
This caddy has been even more useful than I expected. It instantly made my kitchen look cleaner and more organized compared to having wet sponges sitting on the sink. My counters look much tidier now, and the sponges dry out much better. It may seem like a small addition, but it really makes a big difference.
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Reviewed in the United States on May 9, 2026
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GoRetro Girl
Fort Morgan, US
★★★★★ 5
Makes the Sink Area All the More Organized
Color: Silver With Towel Rack - 9.25″, Color: Silver With Towel Rack - 9.25″
At first glance I'm sure most people might think this kitchen accessory is kind of silly; a caddy for your sponge and dish soap? But honestly, it makes the kitchen area look at the more organized and keeps things in place. I sprung for the model with the towel holder because I always feel weird about bacteria sitting in the wet microfiber cloth that I use for cleaning the kitchen countertop and my dining table. The little dowel allows it to dry very quickly. The holder can be configured in a few different ways to accommodate your cleaning items. I like that it's wide enough to comfortably hold the large bottle of dishwashing soap I buy and it's the perfect width for Sponge Mommy/Daddy sponges. I've had it less than a week and haven't had to wash it yet, but it seems like it will hold up well in the dishwasher and won't rust. Since I don't have any sponges on a handle, I may use the removable compartment for those (that you can see on the left in my photo) for other kitchen tools.
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Reviewed in the United States on April 7, 2026

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