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Description
VE-Cadherin Recombinant Rabbit mAb (S-3312-5)Product Specification Host Rabbit Antigen VE Cadherin Synonyms Cadherin 5; 7B4 antigen; Vascular endothelial cadherin (VE cadherin); CD144; CDH5 Immunogen Synthetic Peptide Location Cell membrane, Cell junction Accession P33151 Clone Number S 3312 5 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms, Rt Positive Sample bEnd. 3, mouse lung, rat lung, rat heart Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | VE-Cadherin |
| Synonyms | Cadherin-5; 7B4 antigen; Vascular endothelial cadherin (VE-cadherin); CD144; CDH5 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Cell junction |
| Accession | P33151 |
| Clone Number | S-3312-5 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms, Rt |
| Positive Sample | bEnd.3, mouse lung, rat lung, rat heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
Background
VE-Cadherin (vascular endothelial cadherin, CDH5) is a 140-kDa transmembrane glycoprotein that forms the core of endothelial adherens junctions, where its calcium-dependent homophilic interactions between extracellular EC1-EC5 repeats create a semi-permeable barrier between blood and tissues; its cytoplasmic tail recruits β-catenin, plakoglobin and p120-catenin, linking the junction to the actin cytoskeleton and enabling transmission of shear-stress signals that regulate angiogenesis, vascular remodeling and leukocyte extravasation, while phosphorylation of Y685 and Y658 by Src, VEGFR2 or Tie-2 and subsequent internalization of the complex transiently increases permeability during inflammation, tumor metastasis and atherosclerosis, making VE-cadherin a key therapeutic target in vascular pathologies.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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4.2 ★★★★★
Based on 16 reviews
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Product Reviews
★★★★★ 5
Indestructible Toys My Dobermans ❤️
Size: Large, Color: Mesh Green
Actually Respect! goDog Is a Lifesaver
The variety of size and colors are phenomenal 😇
I have two Dobermans — serious, determined power chewers — and I’ve spent years trying to find toys that survive even a few days.
I’ve tried the big brands (Kong, Goughnuts, Jolly Ball, you name it) — and while some toys last a little while, almost everything eventually ends up shredded, de-squeaked, or in pieces.
goDog toys are the ONLY plush toys my Dobermans won’t destroy.
We own multiple goDog toys now — dragons, dinosaurs, lizards — mostly in the large size (perfect for Dobermans), but even a few medium-sized ones hold up surprisingly well.
Here’s what’s amazing:
• They love them — actually carry them around, toss them, chew them gently, and squeak them happily.
• They do not rip them apart — no matter how much tugging, chewing, or wrestling happens.
• Large sizes are best for Dobermans (and other big breeds) — but even mediums survive for calmer play sessions.
• No ripped seams, no stuffing everywhere, and no destroyed squeakers after months of use.
What makes goDog toys different?
The secret is their Chew Guard Technology —
• A reinforced, high-strength inner mesh layer under the soft plush
• Double-stitched seams
• Durable yet flexible material that somehow resists punctures, tears, and brutal shaking
The outside stays soft and fun, but the inside is built like armor.
It’s NOT a super hard rubber or rough canvas — it still feels like a cuddle toy, but it’s engineered to survive serious chewing.
Materials include:
• Durable polyester plush
• Chew Guard inner lining (high-tensile mesh fabric)
• Reinforced stitching
• Non-toxic squeakers
• Safe for dogs to play with long-term
Real Owner Advice:
• Always size up if you have a heavy chewer — large sizes are a must for Dobermans or similarly strong breeds.
• Medium sizes are fine if you supervise or your dog is more moderate with toys, but the large toys are built tougher overall.
Final Thoughts:
If you have big dogs, strong jaws, or just tired of wasting money on destroyed toys — goDog toys are a must.
No other plush-style toy even comes close.
My Dobermans will destroy almost anything… but they treat their goDog toys like treasured companions. No holes, no rips, just happy dogs.
Follow me here on Amazon for more honest, dog-tested reviews! Like this review if it helped — I’ll be uploading even more proven tough toys and pet essentials soon!
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Reviewed in the United States on April 29, 2025
★★★★★ 4
Surface Fabric is very durable
Size: Small, Color: Hot Pink
Surface Fabric is very durable, but the squeaker didn't last two months. I have urged the manufacturer to find a strong more durable squeaker for their product. My dogs really enoys it when the speaker works. One of his 3 work. I have just bought two more he likes them so much. He takes it to bed every night to catch it once or twice before sleeping. Also loves to catch it a few times during the day.
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Reviewed in the United States on April 11, 2026
★★★★★ 5
Best. Toy. Ever. For My Superchewer!
Size: Large, Color: Skinny Green, Size: Large, Color: Skinny Green
Best toy ever! My dog destroys toys. Usually within about 15 minutes, she has de-squeakered and defluffed them. By the second day, she has tug-of-war-ed them to shreds.
From the time we got this adorable dragon out of the package, she LOVED it. She set to work. It’s been a week, and while she has dewinged him, he lost his squeaker after a few days, and he looks a bit rough, he’s still in one piece! And, we’ve had HOURS of tug-of-war with minimal rips! She’s obsessed 😍 I ordered two more today. We’ve finally found the perfect toy for my baby!
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Reviewed in the United States on January 18, 2026
★★★★★ 5
My 90 lb. Pitbull's All-Time Fave Toy
Size: Large, Color: Coral, Size: Large, Color: Coral
I ordered a plethora of new toys for Bruce to keep him occupied while I am working remotely from home. Poor guy gets so bored while I'm stuck in front of my computer 8+ hours a day. All the other toys are animated, but this one is just a big floppy chewy squeaky toy. Bruce quickly lost interest in all the other chirping, hopping, and twirling toys and fell in love with "Diny". When I opened Diny and gave it to Bruce, he had the elated and surprised look of a 3 yr old at Christmas. And he stayed that happy for hours, and then each time he picked up Diny to play. Diny became his go-to toy over all others (and there are many!). It is well made out of durable fabric, and they did not stuff it full of kapoc (I hate kapoc in dogs toys!). And it is delightfully low-tech. Normally he tears a squeaky toy apart as soon as he can isolate the squeaky mechanism. But cleverly, the squeaky box is loose in the long belly so it moves from one end to the other as the toy is handled. That made it difficult for Bruce to locate it. The toy remained in good condition for 2 weeks of near constant attention by Bruce. But yesterday he zeroed in on the squeaky box and ripped Diny to shreds. I was sad to see Diny go so soon. But boy-howdy was Bruce happy with it. I'm gonna buy another because we liked it so much. And so did I : )
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Reviewed in the United States on May 23, 2024
★★★★★ 5
This is one “under the radar” gem!!
Size: Large, Color: Coral
This is one “under the radar” gem!! Very strong internal squeaker and way tougher than it looks. My big 125lb Shepard-Husky mix gave it heck, then made it his new buddy. He’ll occasionally give it the business but on the whole, it’s surprisingly tough and my big boy loves it. Nice price!!
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Reviewed in the United States on May 10, 2026
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