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Description
Human Coagulation Factor XI OneStep ELISA KitProduct Specification Antigen Coagulation Factor XI Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 2. 0% Inter assay: 3. 5% Sample type Cell culture supernatant; Serum; Plasma EDTA, Plasma Citrate Assay type Sandwich (quantitative) Sensitivity 0. 052 ng mL Range 0. 156 ng mL 10 ng mL
Product Specification
| Antigen | Coagulation Factor XI |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 2.0%； Inter-assay: 3.5% |
| Sample type | Cell culture supernatant; Serum; Plasma-EDTA, Plasma-Citrate |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.052 ng/mL |
| Range | 0.156 ng/mL – 10 ng/mL |
| Recovery | Cell culture supernatant: 89% Serum: 101% Plasma: 109% |
| Assay time | 60 minutes |
| Species reactivity | Hu |
Background
Human Coagulation Factor XI (FXI) is a plasma glycoprotein synthesized primarily in the liver and is a key zymogen within the intrinsic coagulation pathway. Upon activation by Factor XIIa, thrombin, or auto-activation, it converts to the serine protease Factor XIa. This active form then specifically cleaves and activates Factor IX, thereby amplifying the downstream coagulation cascade to generate thrombin and form a stable fibrin clot. Beyond its procoagulant role, FXI is also implicated in various thrombo-inflammatory processes. Notably, genetic deficiency of FXI results in a mild bleeding tendency known as hemophilia C, while elevated levels are considered a risk factor for thrombotic diseases like stroke and venous thromboembolism. Consequently, Factor XI is now a prominent therapeutic target, with inhibitors under development to create safer anticoagulants with potentially reduced bleeding risks.
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