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The Impact of GLP 1 Receptor Agonists on Sedation DOCS Education Ozempic. Mounjaro. Trying to conceive. These three things are colliding in my DMs more than almost anything else right now so let's talk about what the research actually shows (and what GLP 1 Agonists Market Size, Share, Growth Insights 2032 GLP 1 and GIPGLP 1 therapies benefits in diabetes and obesity Gustavo Monnerat posted on the topic LinkedIn This review summarizes how GLP 1 and dual GIP GLP 1 receptor agonists act at the cellular level and their therapeutic applications in metabolic diseases like type 2 diabetes and obesity, highlighting advances in incretin based
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4.1 ★★★★★
Based on 5 reviews
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Product Reviews
★★★★★ 5
Awesome!
**update: we have had this toy for over a year! I have found one other con. Once chewed if you step on it you will immediately drop to the floor in agonizing all encompassing pain or (my personal favorite) say every dirty curse word you have ever heard while clutching your destroyed instep. BUT even though this chewed bone is the demon child of a LEGO and a race car to step on my dogs still love it, still chew it and we haven’t had to replace it yet!
I have an insane chewer where toys usually last us less than 24 hours. It has become almost impossible for us to keep up with toys because of how expensive it has become. This toy is not only insanely durable but she has not left it alone for the 3 days we’ve had it.
I was concerned that being “chicken flavored” would mean stinky or sticky and I was very pleasantly surprised that it was neither! It doesn’t leave a stain once chewed, it doesn’t smell, and it doesn’t have a weird coating on it.
The only con so far is that due to it being so durable and hard it makes a loud noise when dropped on the tile or hardwood which made her nervous toward it at first but now that she’s started working on it she could care less about the noise. Super happy with this purchase and will 100% buy more in various sizes for our other pups.
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Reviewed in the United States on March 26, 2023
★★★★★ 5
⭐⭐⭐⭐⭐ FINALLY! A toy that can handle my furry demolition expert!
Flavor Name: Beef, Size: Large
Let me tell you about Moxie, my 97-pound Rottweiler who has made it her life's mission to destroy every single toy that dares enter our home. This girl has teeth that could probably open cans and jaws that make nutcrackers jealous. I've spent more money on "indestructible" dog toys than I care to admit, only to find sad little pieces scattered across my living room within hours.
BUT THEN... enter the Tikaton Indestructible Dog Chew Toy! 🎉
I'll be honest - I bought this with zero expectations. Just another victim for Moxie's reign of terror, right? WRONG! This bone has been in our house for THREE MONTHS and it's still going strong! Sure, Moxie has made some progress (she's persistent, I'll give her that), but this thing is holding up like a champ against her industrial-strength chompers.
The best part? Moxie is absolutely OBSESSED. She carries this bone around like it's her precious treasure, gnawing away contentedly for hours. It's given my furniture, shoes, and sanity a much-needed break!
Pros:
Actually lives up to the "indestructible" claim (mostly!)
Keeps my destruction-loving pup busy for hours
Great value - lasting months instead of minutes
No weird smell or toxic materials
Cons:
Nothing is truly indestructible when facing Hurricane Moxie, but this comes pretty darn close!
Fellow owners of canine wrecking balls - THIS IS THE ONE! Your wallet and your home will thank you.
Update: Month 4 and still chewing! Moxie approves this message with enthusiastic tail wags.
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Reviewed in the United States on June 5, 2025
★★★★★ 5
Beef is her favorite
Flavor Name: Beef, Size: Large, Flavor Name: Beef, Size: Large
Our Belgian Malinois loves them, her favorite is the beef, as you can see. They last several months, we swap them out around the 3 to 4 month mark.
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Reviewed in the United States on May 16, 2026
★★★★★ 4
Great buy-read update
Flavor Name: Beef, Size: Large
My dog loved it right away. Kept going from his old bone to this one and finally just stuck with this one. My dog is a 90 pound 1.5 year old German Shepherd. The size is fine. I don’t know what the other people were talking about when they said the large was too small for big dogs. It’s not indestructible, after one day there were serious gouges on it, but it looks like it’s going to last quite awhile. I will say, he’s not able to gnaw off little pieces of it, and that’s a great thing.
I couldn’t give it five stars, because we just received it, and the dog has only had it for a few days. So it’s 4 stars.
****UPDATE****
As of Jan. 1, 2021, the bone is in the trash. The thing seemed to get softer and come apart more easily the more he chewed. I was finding little pieces all over and god only knows much of it he swallowed. Now I give it 3 stars.
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Reviewed in the United States on November 22, 2020
★★★★★ 5
Yes it's for aggressive chewers
Flavor Name: Beef, Size: Medium, Flavor Name: Beef, Size: Medium
I have 2 dogs a malti poo and 120 lb pit rotty mix. My son just moved in with his 8 month old pitty/ 90 lbs. needless to say we have purchased sooo many bones and toys, always have to have bones for them all or they argue and fight. This bone we have had for about 8 -9 days.. They all chew on it non stop and it is still fully intact with a few rough areas where they chewed up the suface. The picture was taken today. But keep in mind they will typically go through a large elk antler ($40) in about 4-5 days.. down to splinters. but not this bone. I got the beef. It does have a slight smell, kind of beefy but no worse than some other bones we bought. Only noticed it taking it out of the package. They all enjoy it. I was worried they wouldn't be interested because it's fake.. but no. I will definitely purchase a few more cuz when someone isn't home the pitty will chew shoes or remotes, etc. Every day was a new surprise. But he hasn't touched anything since we got this bone. I would definitely recommend for aggressive chewers and the price is reasonable.
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Reviewed in the United States on May 18, 2025
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