SKU: 99717196010

PXR Recombinant Rabbit mAb (S-2398-43)

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Description

PXR Recombinant Rabbit mAb (S-2398-43)Product Specification Host Rabbit Antigen PXR Synonyms Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor (SXR); NR1I2 Immunogen Synthetic Peptide Location Nucleus Accession O75469 Clone Number S 2398 43 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, HepG2, THP 1, mouse liver, rat liver

Product Specification


Host Rabbit
Antigen PXR
Synonyms Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor (SXR); NR1I2
Immunogen Synthetic Peptide
Location Nucleus
Accession O75469
Clone Number S-2398-43
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample HeLa, HepG2, THP-1, mouse liver, rat liver
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

PXR protein (Pregnane X Receptor) is a nuclear receptor that plays a crucial role in the regulation of drug metabolism and detoxification processes in the body. It is primarily expressed in tissues such as the liver and intestines. When activated by various endogenous and exogenous compounds, including certain drugs, PXR can induce the expression of numerous target genes. These target genes are involved in the production of enzymes like cytochrome P450, which are key for the biotransformation of drugs and other xenobiotics. This helps the body to effectively metabolize and eliminate potentially harmful substances. PXR's activity is important for maintaining homeostasis and ensuring the proper functioning of the body's detoxification systems.

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SKU: 99717196010

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4.4 ★★★★★
Based on 26 reviews
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MAW2002
Louisville, US
★★★★★ 5
Tough toys for tough girls
Color: Ring
I have 3 large dogs that are proficient at destruction and extremely aggressive chewers. Few toys survive them. I bought several of these toys and they have been put through the ringer but still in great shape. Definitely worth it in my book. I wish there were more cute options but cute doesnt typically last for these 3.
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Reviewed in the United States on November 18, 2025
K
Verified Purchase
Kate Yamokoski
Waukegan, US
★★★★★ 5
Great chew toy for my golden retriever .
Color: Ring
My golden retriever loves this toy . And she has not chewed it up . I bought several of them . It is durable and she is an aggressive chewer with toys .
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Reviewed in the United States on May 29, 2025
T
Verified Purchase
The Big Guy of Michigan
Los Angeles, US
★★★★★ 5
Dog chew toy
Color: Ring
Well made, too big & heavy for small-medium dogs.
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Reviewed in the United States on February 2, 2026
Z
Verified Purchase
ZC
Grantham, US
★★★★★ 4
My dogs go CRAZY for these!
Color: Ring
My Pitbull and Frenchie go CRAZY for these! They do have a leathery type smell to them if you’re sensitive to that (doesn’t bother me) and my dogs WILL ingest what they tear off if I don’t watch them closely. Only removing 1 star because of how fast my dogs tear these apart and how deliciously enticing they apparently are to ingest, but my dogs may just be psychopaths. :)
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Reviewed in the United States on September 13, 2025
H
Verified Purchase
Hannah Hettasch
Omaha, US
★★★★★ 5
Not the most durable, but my dog LOVES it.
Style: Plush Surprise Color, Size: 24"
My boyfriend’s dog had the small version from Petsmart and she has been very gentle with it since she likes it so much. I decided to surprise her with this 24 inch one for Christmas. She was obsessed! It’s cute, it’s very soft, and has a big squeaker in the top, which she loves! She was a little more tough on it and it did get some rips 12 hours in, but it is still in one piece at the moment and brings lots of joy. The dog is a medium/large size. Dog toys can be so expensive. I personally think the was a great price despite not being the most durable. I may purchase again next year!
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Reviewed in the United States on January 3, 2026

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