SKU: 93075619604

Polyneuropathie 2 (LPN2) - Leonberger

$44.10 $49.00
Save 10%
No.2 Bestseller on 2pierres.com >

Pay in installments of $12.25 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 25 - Jul 30

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Polyneuropathie 2 (LPN2) - LeonbergerPolyneuropathie (PN) ist eine fortschreitende neurologische Erkrankung mit typischen Anzeichen wie Hypotonie, Muskelatrophie infolge von Denervierung und abnormalen motorischen Zeichen. Frhe Anzeichen sind Kehlkopflhmung, inspiratorischer Stridor und Dyspnoe und werden als starker Hinweis auf eine Neuropathie angesehen, die sich spter weiterentwickeln kann. Klinische Anzeichen beim Leonberger variieren stark und haben ein unterschiedliches

Polyneuropathie (PN) ist eine fortschreitende neurologische Erkrankung mit typischen Anzeichen wie Hypotonie, Muskelatrophie infolge von Denervierung und abnormalen motorischen Zeichen. Frühe Anzeichen sind Kehlkopflähmung, inspiratorischer Stridor und Dyspnoe und werden als starker Hinweis auf eine Neuropathie angesehen, die sich später weiterentwickeln kann. Klinische Anzeichen beim Leonberger variieren stark und haben ein unterschiedliches Auftretensalter von <1 Jahr bis 10 Jahre. Eine Mutation im GJA9-Gen wurde identifiziert, die eine weitere Form der PN darstellt, die als Leonberger Polyneuropathie 2 (LPN2) bezeichnet wird. Mutationen, die mit LPN1 und LPN2 assoziiert sind, machen nur 1/3 aller Fälle von PN beim Leonberger aus.

Vererbung: autosomal dominant

Mutation: GJA9 gene

Gentest: Die für den Test verwendete Methode ist äußerst genau und ermöglicht eine vollständige Unterscheidung zwischen betroffenen Tieren, Trägern und gesunden Hunden. Tests können in jedem Alter durchgeführt werden.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 93075619604

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 24 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
L
Verified Purchase
Luis n Dee
Waukegan, US
★★★★★ 5
Love the benefits of tallow! It’s all I use!
Scent: Lavender
I am a loyal Lotus customer having their face tallow cream on authorship. It’s all I use on my skin & for my teenage daughter. Surprised when I saw they had their bars on Amazon so I placed an order. They are wonderful tallow bars just like I’d expect from Lotus! Smooth, creamy & lather so beautifully! My skin felt so clean & moisturized after my bath. No nasty chemicals, all natural skincare! Definitely buy these bars! I don’t have any skin conditions or concerns I just would rather use natural high quality ingredients, but I can see if you have sensitive skin or any skin issues this would help! Thank you for making high quality skincare!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 22, 2026
R
Verified Purchase
Rissa89
Pawtucket, US
★★★★★ 5
Worth the price!!
Scent: Unscented
I honestly love this soap. I have it in a pure cotton pouch and that helps with the lather. Yes, the bars are small, but these three have lasted me almost 5 months. For the ingredients in it, and how it makes your skin feel, it is worth the price. I’m running low so will be replenishing soon. Far better than your basic bar soap from the store!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 20, 2026
J
Verified Purchase
Jacob
Massapequa, US
★★★★★ 5
Good Product
Scent: Unscented
Honestly one of the better bar soaps I’ve tried in a while. It’s priced a little higher than what you’d grab off a drugstore shelf, but you can tell pretty quickly that you’re getting something different it lasts longer, feels more substantial, and actually does something for your skin rather than just cleaning it. The lather is rich without feeling heavy, and after a few days of use you notice your skin staying softer without needing to reach for lotion right after. If you’re on the fence about upgrading your soap, this one’s worth trying.​​​​​​​​​​​​​​​​
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 3, 2026
F
Verified Purchase
fingercast
Grantham, US
★★★★★ 4
Great soap but does not last long
Scent: Unscented
Good soap. Lathers well. Does not last long for the price.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 11, 2026
S
Verified Purchase
Sarah
West Palm Beach, US
★★★★★ 5
I’ve never loved a bar of soap so much.
Scent: Unscented
For starters, I suffer with severe sensitive skin, Eczema (which also has a huge gut health component) - however I’ve been struggling pretty bad the last few months. In my search to find more natural and nontoxic options, I stumbled upon castile soap - I’ve been using it to wash my dishes, clothes, skin. Finding out that the alkalinity of the soap can destroy sensitive skin barriers (even with diluting). I think it is been the leading cause of my skin dryness. (Despite lathering up with things like organic Shea butter and castor oil). I was getting very frustrated and very stressed and I found this family owned company. I’ve always wanted to try more tallow products, and know how amazing honey and castor oil is for health and rejuvenation (inside and out). I figured what the heck this is a pretty decent price. When I say I do not want to stop using the bar so I mean it like it is now becoming a struggle for me to get out of the shower because I want to keep blathering up because it feels so good. As a bartender and someone who hates having dirty hands - I really hate washing my hands, despite how much I feel obligated to do it. I’m contemplating bringing a bar of soap With me wherever I go so that I have good soap to use 😆. I’m about to buy some from my mom and try other products. I will update if my skin issues have subsided (in a month or so I reckon). I am getting an Eczema patch on my stomach/torso area, my inner thigh to my knee, and back of legs as well. As well as for the last month despite how much dry skin I take off my face, And how much castor oil I rub in - even with a moist appearing face - the flaky skin pokes through. I immediately felt soft skin upon using this product on my face. Normally, I would test out a small area, but with only a few ingredients I was like screw it. I ran out of soap and it’s either that or using watered down castile. Please give this a try. I cannot attest for the scented versions. Also, I saw someone say that it burned their eyes? Castile burns my eyes - this, does not. (And I probably scrub my eyes harder than I should post makeup remover - which is a balm - and just on the eyes).
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 3, 2026

recommand products

Spezialmikrometer versetzt Innenmikrometer
170.00
Gefra Sinustisch Sinus Schleifscheiben Abrichtgerät 100mm
400.00
TESA Prismamikrometer 5-20mm
80.00
Gressel PS 150 Schraubstock Werkbankschraubstock
125.00
Schaublin W20 Spannzangen QUADRATISCH
200.00