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Description
APC Rat Anti-Mouse CD193 Antibody (S-R699)Product Specification Host Rat Antigen CD193 Synonyms Probable C C chemokine receptor type 3; C C CKR 3; CC CKR 3; CCR 3; CCR3; CKR3; Macrophage inflammatory protein 1 alpha receptor like 2 (MIP 1 alpha RL2); Cmkbr1l2; Cmkbr3 Location Cell membrane Accession P51678 Clone Number S R699 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample Fresh C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml
Product Specification
| Host | Rat |
| Antigen | CD193 |
| Synonyms | Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; Macrophage inflammatory protein 1-alpha receptor-like 2 (MIP-1 alpha RL2); Cmkbr1l2; Cmkbr3 |
| Location | Cell membrane |
| Accession | P51678 |
| Clone Number | S-R699 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | Fresh C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 0.25μg per million cells in 100μl volume | Ms |
Background
CD193, also known as C-C motif chemokine receptor 3 (CCR3), is a member of the G protein-coupled receptor (GPCR) family, characterized by its seven-transmembrane structure. It is a high-affinity receptor for various chemokines, including eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). CD193 is highly expressed on eosinophils, basophils, and airway epithelial cells, and is also detected in CD4+ T cells, mast cells, monocytes, platelets, and CD34+ hematopoietic progenitor cells. This receptor plays a crucial role in mediating the migration and activation of eosinophils and other inflammatory cells, contributing to allergic responses and inflammatory processes in conditions such as asthma and allergic rhinitis. Additionally, CD193 has been identified as a co-receptor for HIV-1 entry into cells.
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