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Description
Human CD45, His tagProduct Specification Species Human Synonyms Receptor type tyrosine protein phosphatase C, Leukocyte common antigen (L CA), T200, PTPRC Accession P08575 Amino Acid Sequence Protein sequence(P08575, Gln26 Lys577, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen (L-CA), T200, PTPRC |
| Accession | P08575 |
| Amino Acid Sequence | Protein sequence(P08575, Gln26-Lys577, with C-10*His) QSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:62.4kDa Actual:100-150kDa |
| Purity | ＞95% by SDS-PAGE |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling. CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia. CD45 colocalizes with lipid rafts on AML cells, which contributes to elevated GM-CSF signal intensity involved in proliferation of leukemic cells.
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4.4 ★★★★★
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Product Reviews
★★★★★ 5
My 75 year old hands appear softer and younger!
Avene Cicalfate Restorative Hand cream leaves my hands feeling very soft! A little goes a long way, I have had mine for a year. Soon I will be purchasing another tube. Yes, it is a little pricey for a hand cream, but does the job better then any other product I have used on my hands. Highly recommend this hand cream if you have dry, sensitive skin. It also has no added fragrance which I really appreciate!
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Reviewed in the United States on June 4, 2025
★★★★★ 5
Excellent product at a very good price. I will buy it again.
This is an excellent product at a fair price. The cream creates a barrier that protects the skin, while mosturizes it. leaves hands very soft, and it doesn't feel greasy. I know that this is a favorite brand (Avene) in France, and Amazon offers it at a very good price. I will buy it again, from Amazon. I bought it this year in Paris, and it was more expensive there.
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Reviewed in the United States on May 27, 2015
★★★★★ 1
Drying formula and smell bad
Smell so bad and made my hands dry instead of moisturizing. The formula is watery. Maybe it’s fake or expired I am not sure.
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Reviewed in the United States on December 25, 2025
★★★★★ 5
I like it!
Color: Angel
This is a very interesting addition to my garden. The angel is nice. The light isn’t real bright but it’s bright enough. There were no instructions in the box but I finally found the on/off switch under the light part. The item wasn’t damaged, it was packed well and arrived when expected.
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Reviewed in the United States on May 18, 2026
★★★★★ 2
Poor size statue with very weak light
Color: Angel
This item is very small. The angel is very nice but tiny. The light is solar and works but it is very dim when it comes on. I would not purchase this item again. I feel this item is over priced and falls short of all expectations.
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Reviewed in the United States on May 31, 2026