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Description
TRIM63 Recombinant Rabbit mAb (S-2304-110)Product Specification Host Rabbit Antigen TRIM63 Synonyms E3 ubiquitin protein ligase TRIM63; Iris RING finger protein; Muscle specific RING finger protein 1 (MuRF 1; MuRF1); RING finger protein 28; RING type E3 ubiquitin transferase TRIM63; Striated muscle RING zinc finger protein; Tripartite motif containing protein 63; IRF; MURF1; RNF28; SMRZ Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q969Q1 Clone Number S 2304 110 Antibody
Product Specification
| Host | Rabbit |
| Antigen | TRIM63 |
| Synonyms | E3 ubiquitin-protein ligase TRIM63; Iris RING finger protein; Muscle-specific RING finger protein 1 (MuRF-1; MuRF1); RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; Striated muscle RING zinc finger protein; Tripartite motif-containing protein 63; IRF; MURF1; RNF28; SMRZ |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q969Q1 |
| Clone Number | S-2304-110 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse heart, mouse skeletal muscle, rat heart, rat skeletal muscle |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Ms, Rt |
| IHC-P | 1:200-1:5000 | Hu, Ms, Rt |
Background
TRIM63, also known as MuRF1 (Muscle RING Finger 1), is a muscle-specific E3 ubiquitin ligase encoded by the TRIM63 gene, primarily expressed in cardiac and skeletal muscle, where it plays a critical role in regulating muscle protein homeostasis by ubiquitinating sarcomeric proteins such as MYH6, MYBPC3, and cardiac troponin I for proteasomal degradation, thereby influencing muscle atrophy and hypertrophy; structurally, TRIM63 belongs to the tripartite motif (TRIM) family and contains an N-terminal RING domain, B-box, coiled-coil motifs, and a C-terminal acidic tail, and mutations in TRIM63 have been implicated in human hypertrophic cardiomyopathy due to impaired E3 ligase activity and disrupted protein degradation pathways.
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