Pay in installments of $45.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 11 - Aug 16
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
FITC Mouse Anti-Human CD163 Antibody (S-3028)Product Specification Host Mouse Antigen CD163 Synonyms Scavenger receptor cysteine rich type 1 protein M130; Hemoglobin scavenger receptor; M130 Location Cell membrane Accession Q86VB7 Clone Number S 3028 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability &
Product Specification
| Host | Mouse |
| Antigen | CD163 |
| Synonyms | Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor; M130 |
| Location | Cell membrane |
| Accession | Q86VB7 |
| Clone Number | S-3028 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD163 is a cysteine-rich scavenger receptor (a member of the SRCR-SF family) encoded by the CD163 gene, primarily expressed on the surface of monocytes and macrophages, with a molecular weight of approximately 130 kDa. Its structure consists of an extracellular domain with nine SRCR domains, a transmembrane segment, and a cytoplasmic tail. CD163 specifically recognizes the hemoglobin-haptoglobin complex (Hb-Hp) and free hemoglobin (FHb), playing a crucial role in hemoglobin clearance and iron metabolism. CD163 exhibits significant immunomodulatory functions by suppressing pro-inflammatory cytokines (e.g., TNF-α, IL-6) and promoting anti-inflammatory factors (e.g., IL-10), thereby mitigating inflammatory responses. It also exerts antioxidant effects through pathways such as HO-1 activation during oxidative stress. The soluble form (sCD163), generated by ectodomain shedding, is elevated in conditions like cirrhosis, diabetes, and rheumatoid arthritis, making it a potential biomarker for inflammatory diseases. Additionally, CD163 serves as the key receptor for porcine reproductive and respiratory syndrome virus (PRRSV), highlighting its importance in veterinary research and disease-resistant breeding strategies.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy