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Description
SDF-1β/CXCL12β Protein, HumanProduct Specification Species Human Accession P48061 Amino Acid Sequence Lys22 Met93 Expression System E. coli Molecular Weight Approximately 8. 5 kDa, a single non glycosylated polypeptide chain containing 72 amino acids. Purity 97% by SDS PAGE or HPLC. Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH 7. 4. Reconstitution Before use this product, please read the direction below carefully. This vial
Product Specification
| Species | Human |
| Accession | P48061 |
| Amino Acid Sequence | Lys22-Met93 |
| Expression System | E.coli |
| Molecular Weight | Approximately 8.5 kDa, a single non-glycosylated polypeptide chain containing 72 amino acids. |
| Purity | ＞97% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
CXCL12 also known as SDF-1 is belonging to the CXC chemokine family. It is encoded by the CXCL12 gene. In recently study, Human CXCL12 is expressed as six isoforms that differ only in the C-terminal tail. And all SDF-1 isoforms undergo proteolytic processing of the first two N-terminal amino acids. In all SDF-1 isoforms, SDF-1β is the canonical sequence. It has the complete amino acids in the C-terminal tail. On the cell surface, the receptor for this chemokine is CXCR4 and syndecan 4. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. CXCL12 is a very important factor in carcinogenesis and the neovascularization linked to tumor progression. Recombinant human Stromal-Cell Derived Factor-1 beta/CXCL12 beta is an 8.5kDa protein containing 72 amino acid residues.
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