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Description
MIP-3/CCL23 Protein, HumanProduct Specification Species Human Synonyms CKB 8,MIP 3,MIPIF 1 Accession P55773 Amino Acid Sequence Arg24 Asn94 Expression System E. coli Molecular Weight Approximately 11. 4 kDa, a single non glycosylated polypeptide chain containing 99 amino acids. Purity 97% by SDS PAGE or HPLC. Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 20 mM PB, with 150 mM NaCl, pH 7. 4. Reconstitution Before use this product,
Product Specification
| Species | Human |
| Synonyms | CKB-8,MIP-3,MIPIF-1 |
| Accession | P55773 |
| Amino Acid Sequence | Arg24-Asn94 |
| Expression System | E.coli |
| Molecular Weight | Approximately 11.4 kDa, a single non-glycosylated polypeptide chain containing 99 amino acids. |
| Purity | ＞97% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20 mM PB, with 150 mM NaCl, pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
MIP-3 is a CC chemokine that signals through the CCR1 receptor. Highly expressed in adult lung, liver, skeletal muscle and pancreas, this protein shows strong chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. It elicits the effects by binding to CCR1. CCL23 is reported that it can be cleaved into four forms: CCL23 (19-99) , CCL23 (22-99) , CCL23 (27-99) , CCL23 (30-99) . Recombinant Human MIP-3 is an 11.3kDa protein containing 99 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
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