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Description
Antithrombin III Recombinant Rabbit mAb (SDT-294-211)Product Specification Host Rabbit Antigen Antithrombin III Synonyms ATIII, Serpin C1 Immunogen Recombinant Protein Location Secreted, Extracellular space Accession P01008 Clone Number SDT 294 211 Antibody Type Recombinant mAb Application WB, IP Reactivity Hu Cross Reactivity Does not recognize thrombin, PIC complex, tPA PAI 1 complex Purification Protein A Concentration 0. 5 mg ml Tag N A Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | Antithrombin III |
| Synonyms | ATIII, Serpin C1 |
| Immunogen | Recombinant Protein |
| Location | Secreted, Extracellular space |
| Accession | P01008 |
| Clone Number | SDT-294-211 |
| Antibody Type | Recombinant mAb |
| Application | WB, IP |
| Reactivity | Hu |
| Cross Reactivity | Does not recognize thrombin, PIC complex, tPA-PAI-1 complex |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Tag | N/A |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 |
Background
Antithrombin III (AT III) is primarily a potent anticoagulant with independent anti-inflammatory properties. AT III irreversibly inhibits serine proteases (e.g. activated factor X and thrombin) in a one-to-one ratio, with the generation of protease–AT III complexes. Heparin prevents AT III from interacting with the endothelial cell surface by binding to sites on the AT III molecule, competing for the AT III binding site, and reducing AT III’s ability to interact with its cellular receptor [PMID: 26862016].
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