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Description
HMGB2 His Tag Protein,HumanProduct Specification Species Human Synonyms High Mobility Group Protein B2; High Mobility Group Protein 2; HMG 2; HMGB2; HMG2 Accession P26583 Amino Acid Sequence Gly2 Glu209 Expression System HEK293 Molecular Weight 25. 07 KDa Purity >95% by SDS PAGE Endotoxin <1EU g Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris HCl, 100mM NaCl, pH 8. 0. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or
Product Specification
| Species | Human |
| Synonyms | High Mobility Group Protein B2; High Mobility Group Protein 2; HMG-2; HMGB2; HMG2 |
| Accession | P26583 |
| Amino Acid Sequence |
Gly2-Glu209
|
| Expression System | HEK293 |
| Molecular Weight | 25.07 KDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris-HCl, 100mM NaCl, pH 8.0. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Background
High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
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