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Description
Alexa Fluor 647-Labeled GPC3 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms Glypican 3 Accession P51654 1 Amino Acid Sequence Gln25 His559, with C terminal Human IgG1 Fc Expression System HEK293 Molecular Weight 95 180kDa (Reducing) Conjugation Alexa Fluor 647 Tag Human Fc Tag Physical Appearance Liquid Storage Buffer PBS, pH7. 4 Stability & Storage 12 months from date of receipt, lyophilized powder stored at 20 to 80. 3 months, 20 to 80 under sterile conditions after
Product Specification
| Species | Human |
| Synonyms | Glypican-3 |
| Accession | P51654-1 |
| Amino Acid Sequence | Gln25-His559, with C-terminal Human IgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 95-180kDa (Reducing) |
| Conjugation | Alexa Fluor® 647 |
| Tag | Human Fc Tag |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.nature modern pathology original article article Published: 09 May 2008. Sarit Aviel-Ronen, Suzanne K Lau, Melania Pintilie, Davina Lau, Ni Liu, Ming Sound Tsao & Serge Jothy Modern Pathology volume 21, pages817–825 (2008)Cite this article. |
Background
Glypican-3 (GPC3) belongs to a six-member family of membrane-bound heparan sulfate proteoglycans with a gene that is localized to Xq26.2. GPC3 belongs to a family of cell-surface heparan sulfate proteoglycans and is highly expressed during embryogenesis and organ development. GPC3 has limited expression in adult tissues, including lung, ovaries, mammary epithelium, and mesothelium. Normally, the liver does not express detectable levels of GPC3, but it has been observed to be highly upregulated in hepatocellular carcinomas and hepatoblastomas. Glypican-3 has been shown to play a role in the control of cell growth through the induction of apoptosis. Mutations in glypican-3 result in cell overgrowth. Among all mammalian glypicans, only mutation of GPC3 is associated with a phenotype in humans. GPC3 spans more than 500 kb of genomic DNA and contains 8 exons. Loss-of-function mutations in GPC3 result in overgrowth of many organs (Simpson-Golabi-Behmel syndrome), including the liver, which has been confirmed using GPC3-deficient mice. This observation suggests that GPC3 plays a role in growth suppression and organ size control. GPC3 is highly expressed in yolk sac tumors and choriocarcinomas, with a cytoplasmic staining pattern. It is only variably expressed in teratomas and is absent in germinomas and embryonic carcinomas.
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