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Description
AHR Recombinant Rabbit mAb (S-2370-150)Product Specification Host Rabbit Antigen AHR Synonyms Aryl hydrocarbon receptor; Ah receptor; AhR; Class E basic helix loop helix protein 76 (bHLHe76); BHLHE76 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P35869 Clone Number S 2370 150 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample A204, HepG2, A431, MCF7, PC 3, C2C12, mouse testis, rat liver, COS 7 Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | AHR |
| Synonyms | Aryl hydrocarbon receptor; Ah receptor; AhR; Class E basic helix-loop-helix protein 76 (bHLHe76); BHLHE76 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P35869 |
| Clone Number | S-2370-150 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | A204, HepG2, A431, MCF7, PC-3, C2C12, mouse testis, rat liver, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| ICC | 1:500 | Hu |
Background
The aryl hydrocarbon receptor (AHR) is an evolutionarily conserved, ligand-activated transcription factor that resides primarily in the cytoplasm as part of an HSP90-containing multiprotein complex; upon binding planar aromatic ligands—ranging from environmental pollutants such as dioxins and polycyclic aromatic hydrocarbons to endogenous or dietary molecules like tryptophan photoproducts and flavonoids—it translocates to the nucleus, heterodimerizes with its partner ARNT (HIF-1β), and binds xenobiotic response elements (XRE/DRE) to drive transcription of genes involved in xenobiotic metabolism (e.g., CYP1A1), but it also exerts broad non-genomic and non-canonical actions by crosstalking with NF-κB, Wnt, MAPK, and hypoxia signaling pathways, thereby modulating immune cell differentiation, inflammatory cytokine production, antioxidant responses, cell cycle checkpoints, and even osteoclastogenesis, placing AHR at the hub of environmental sensing, metabolic homeostasis, immune tolerance, and pathologies including autoimmunity, cancer, osteoporosis, and premature aging.
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