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Description
Biotin Mouse Anti-Human/Mouse T-Bet Antibody (S-4477)Product Specification Host Mouse Antigen T Bet Synonyms T box transcription factor TBX21; T cell specific T box transcription factor T bet; Transcription factor TBLYM; TBET; TBLYM; TBX21 Location Nucleus Accession Q9UL17Q9JKD8 Clone Number S 4477 Antibody Type Mouse mAb Isotype IgG1,k Application ICFCM Reactivity Hu, Ms Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage
Product Specification
| Host | Mouse |
| Antigen | T-Bet |
| Synonyms | T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM; TBET; TBLYM; TBX21 |
| Location | Nucleus |
| Accession | Q9UL17、Q9JKD8 |
| Clone Number | S-4477 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Hu, Ms |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Hu |
Background
T-bet (T-box transcription factor TBX21) is a master regulator protein essential for the differentiation and function of T helper 1 (Th1) cells, playing a pivotal role in the adaptive immune response against intracellular pathogens such as viruses and bacteria. Encoded by the TBX21 gene, this nuclear transcription factor binds to specific DNA sequences to activate the expression of hallmark Th1 cytokines, most notably interferon-gamma (IFN-γ), while simultaneously repressing the development of alternative T cell lineages like Th2 and Th17 by inhibiting their respective lineage-defining transcription factors (GATA3 and RORγt). Beyond its critical function in CD4+ T cells, T-bet also governs the maturation and cytotoxic potential of CD8+ T cells and natural killer (NK) cells, thereby orchestrating a robust cell-mediated immunity; however, its dysregulation or overexpression is implicated in various autoimmune disorders and chronic inflammatory conditions, making it a significant target for immunotherapeutic interventions aimed at modulating immune balance.
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