SKU: 19279568468

PSME4 Recombinant Rabbit mAb (S-3132-44)

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Description

PSME4 Recombinant Rabbit mAb (S-3132-44)Product Specification Host Rabbit Antigen PSME4 Synonyms Proteasome activator complex subunit 4; Proteasome activator PA200; Protein BLM10 homolog (Blm10; hBlm10); BLM10; KIAA0077; PSME4 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q14997 Clone Number S 3132 44 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample 293T, K562, HeLa, HepG2, RAW264. 7, mouse heart, mouse testis,

Product Specification


Host Rabbit
Antigen PSME4
Synonyms Proteasome activator complex subunit 4; Proteasome activator PA200; Protein BLM10 homolog (Blm10; hBlm10); BLM10; KIAA0077; PSME4
Immunogen Synthetic Peptide
Location Cytoplasm, Nucleus
Accession Q14997
Clone Number S-3132-44
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample 293T, K562, HeLa, HepG2, RAW264.7, mouse heart, mouse testis, mouse pancreas, C6, rat heart, rat testis
Predicted Reactivity Bv, Xe
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
IHC-P 1:500 Hu, Ms, Rt
ICC 1:500 Hu, Ms, Rt

Background

PSME4 (Proteasome Activator Subunit 4), also known as PA200 or Blm10 in yeast, is a nuclear proteasome activator that uniquely stimulates the peptidase activity of the 20S core particle through a gate-opening mechanism independent of ATP and ubiquitin conjugation. Structurally, PSME4 contains an HbYX (hydrophobic-tyrosine-X) motif at its C-terminus that docks into the inter-subunit pockets of the 20S α-ring, inducing conformational changes that facilitate substrate entry into the catalytic chamber. Unlike the ATP-dependent 19S regulatory particle or the PA28/11S REG family, PSME4 forms a dome-shaped homodimer that caps the 20S proteasome and preferentially promotes the degradation of unstructured peptides and certain natively disordered proteins, including acetylated histones and unstructured regions of prion-like proteins. PSME4 plays critical roles in spermatogenesis, where it is highly expressed in testis and essential for histone-to-protamine exchange during sperm chromatin remodeling, as well as in DNA damage response and cellular stress adaptation. Dysregulation of PSME4 has been implicated in various pathological conditions, including male infertility, neurodegenerative disorders characterized by protein aggregation, and cancer, where its expression levels correlate with tumor progression and therapeutic resistance in certain malignancies.

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SKU: 19279568468

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Mar Ronquillo
Lake Worth, US
★★★★★ 3
I wanted to love these
Size: 9, Color: Black Leather
These are very good looking in person, especially the buckles and the pop of red on black. Alas, I have another pair of Marc Joseph shoes to compare comfort and fit, and this pair simply hurts my feet.
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Reviewed in the United States on May 31, 2026
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Wei
Port Orchard, US
★★★★★ 5
Fitness
Size: 9, Color: Black Leather
Comfortable
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Reviewed in the United States on June 5, 2026
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K 8bro
Chelsea, US
★★★★★ 4
Fit over a rather large bunion!
Size: 13 Wide, Color: Mocha Grainy Leather
Very comfortable…didn’t pinch toe bed. Attractive!
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Reviewed in the United States on March 10, 2026
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Richard H.
Port Orchard, US
★★★★★ 1
These shoes ARE NOT LEATHER as advertised!
Size: 14, Color: Black
I own 4 pair of Marc Joseph shoes. All were Amazon advertised as Leather uppers and received as such. Made in Brazil out of real leather. Good quality shoes and a fair price. My recent purchases of 2 pair of Marc Jospeh shoes are Amazon advertised as" Leather Uppers". They are NOT leather and I sent them back to Amazon. Made in China. To me this is a bait and switch. Product descriptions should be honest and complete and reveal origin. My previous purchases stated "Made in Brazil" and "Leather Uppers." Since they were Marc Joseph, I thought these 2 recent pair were creditably described so I ordered based on my prior satisfied experience. Shame on me. Marc Joseph has lost a loyal customer.
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Reviewed in the United States on January 30, 2025
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Amazon Customer
Houston, US
★★★★★ 5
Great shoes
Size: 12, Color: Black
These are great. We buy them again and again
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Reviewed in the United States on May 4, 2026

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