SKU: 19581520877

Biotin Rat Anti-Mouse Ly-6C Antibody (S-R523)

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Description

Biotin Rat Anti-Mouse Ly-6C Antibody (S-R523)Product Specification Host Rat Antigen Ly 6C Synonyms Lymphocyte antigen 6C1; Ly 6C1; Ly6c1 Location Cell membrane Accession P0CW02 Clone Number S R523 Antibody Type Rat mAb Isotype IgG2c,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 0. 5 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt

Product Specification


Host Rat
Antigen Ly-6C
Synonyms Lymphocyte antigen 6C1; Ly-6C1; Ly6c1
Location Cell membrane
Accession P0CW02
Clone Number S-R523
Antibody Type Rat mAb
Isotype IgG2c,k
Application FCM
Reactivity Ms
Positive Sample C57BL/6 mouse bone marrow
Purification Protein G
Concentration 0.5 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1μg per million cells in 100μl volume Ms

Background

Ly-6C is a glycosylphosphatidylinositol-anchored cell-surface protein belonging to the Ly-6/uPAR/α-neurotoxin superfamily, selectively expressed on murine monocyte and T-cell subsets where it serves as a dynamic lineage and activation marker—its high level on pro-inflammatory “classical” monocytes (CD11b⁺Ly-6C^hi) enables their recruitment via CCR2 to inflamed tissues, whereas Ly-6C^lo monocytes patrol vasculature and replenish resident macrophages, and transient up-regulation on CD8⁺ T cells correlates with effector differentiation; structurally it forms a three-finger α-helical bundle that can laterally associate with lipid rafts and signaling partners such as T-cell receptor or integrin complexes to modulate calcium flux, cytokine release, and adhesion, thereby critically steering innate–adaptive immune crosstalk in infections, autoimmunity, and cardiovascular disease.

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SKU: 19581520877

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4.1 ★★★★★
Based on 25 reviews
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Product Reviews
C
Verified Purchase
Christopher Barrett
Natrona Heights, US
★★★★★ 5
This is the book I've been waiting for!!!
Format: Hardcover
This book has a ton of great information for fans of the first 6 Final Fantasy games. It includes artwork, sketches, maps, computer renderings, and more! Check out the video flip through of the book that I added. If you are a fan, you won't be disappointed! Note: many characters, monsters, and locations are shown with Japanese language (Katakana or Hiragana most often - sometimes Kanji) with a Romaji translation (such as Kokaturisu for Cockatrice) and a final English translation. Note that much of this book is based off multiple versions of the games - often the PSP / PS1 versions for 1, 2, 4, 5 and DS for 3. Just a note because translations are different for each version. Also some of the sprites shown in character models are from later releases, not original. But it is certainly forgivable since they often show the sprites for multiple versions. I am just pawing through it non-stop. I feel like a kid when I got the first Final Fantasy and literally wore out the map/monster chart that was included!
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Reviewed in the United States on July 24, 2018
M
Verified Purchase
Maleena White
Whiting, US
★★★★★ 5
Great gift for Final Fantasy Enthusiasts
Format: Hardcover
My brother in law has played many of the original Final Fantasy games and has always enjoyed the art style. My husband purchased this book for him as a birthday gift and my brother in law has thoroughly enjoyed flipping through this book. The hardback cover is very sturdy and the entire book is beautiful with interesting character facts throughout.
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Reviewed in the United States on January 25, 2024
J
Verified Purchase
JDS
Lexington, US
★★★★★ 5
Even better than expected
Format: Hardcover
This is a really good quality book both in form and content. Its pretty big both in size and thickness, its actually taller than i thought and is very well made with beautiful print. If you are a fan of Final Fantasy or a fan of videogame artwork its a great item to add to your collection. I'd love to get the other two volumes as well.
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Reviewed in the United States on October 22, 2024
J
Verified Purchase
Jonathon Burke
Los Angeles, US
★★★★★ 5
An interesting read for fans of the classic series.
Format: Hardcover
The Ultimania is a nice collection of background info and original artwork for the series, and this book details the first six entries that appeared on Nintendo systems between 1987 and 1994. For fans of the 8-bit era, you may be a bit disappointed to find their sections a bit light on content, but they do feature gorgeous artwork from Yoshitaka Amano, Akihiko Yoshida, and other artists who worked on the remakes for the Wonderswan and PSP versions. There is also some neat background info like notes and outlines from the titles early development. The real meat of the book comes from the 16-bit era entries which detail some interesting info not usually seen, such as artwork of the characters by the staff, dungeon design details, and a few minor cut content. If you're a serious fan of the franchise and can't read Japanese making the 20th and 25th anniversary Japanese Ultimania books nothing more than an art book for you, then this is a great buy for super fans.
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Reviewed in the United States on July 12, 2019
C
Verified Purchase
Chris Leathco
Waukegan, US
★★★★★ 4
Great book, fast but shoddy shipping
Format: Hardcover, Format: Hardcover
The book is exactly what I knew it would be: a translated version of the Ultimania books released for the first six Final Fantasy games. These books are heavy on artwork but also contain many factoids about the games. Don't expect the amount of info that was in the Zelda Encyclopedia or Hyrule Historia books from Dark Horse, but significantly more than what was in the Zelda Art and Artifacts book. Lots of art but also a decent amount of info on the first 6 titles in the Final Fantasy series. More distressing was the shipping method of the book. The book was shipped in a cardboard box, non-form fitting so it shook around a lot. Book was shipped by Amazon Warehouse and condition was listed as Very Good. It may have been Very Good when it left the warehouse, but it took a beating on its way here, as shown by the photos on this review. The book is still quite readable, and the damage is not so severe as the book is falling apart, but it definitely took a few hard hits on its way that would have been not nearly as damaging if it had either been shipped in bubble wrap or at least a form fitting box.
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Reviewed in the United States on August 11, 2018

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