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Description
Alexa Fluor® 488 Mouse Anti-Human Granzyme A Antibody (S-3175)Product Specification Host Mouse Antigen Granzyme A Synonyms CTL tryptase; Cytotoxic T lymphocyte proteinase 1; Fragmentin 1; Granzyme 1; Hanukkah factor (H factor; HF); CTLA3; HFSP; GZMA Location Secreted Accession P12544 Clone Number S 3175 Antibody Type Mouse mAb Isotype IgG1,k Application ICFCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage
Product Specification
| Host | Mouse |
| Antigen | Granzyme A |
| Synonyms | CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor (H factor; HF); CTLA3; HFSP; GZMA |
| Location | Secreted |
| Accession | P12544 |
| Clone Number | S-3175 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Hu |
Background
Granzyme A (GZMA) is a 28 kDa serine protease stored in the cytotoxic granules of CD8⁺ T cells and NK cells; upon immunological synapse formation, it enters target cells together with perforin and cleaves after Lys or Arg residues to hydrolyze SET complex proteins (including the SET, APE1, and HMGB2 nucleases), thereby disrupting DNA repair and initiating a caspase-independent, oxidative DNA-damage cell death pathway that manifests as single-stranded DNA nicks, mitochondrial dysfunction, and plasma membrane perforation, while extracellularly it can process extracellular matrix components and cytokine precursors to modulate inflammation, vascular integrity, and antiviral immunity.
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