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Description
S-RMab® Stat6 Recombinant Rabbit mAb (SDT-337-32)Product Specification Host Rabbit Antigen Stat6 Synonyms IL 4 Stat, Signal transducer and activator of transcription 6 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P42226 Clone Number SDT 337 32 Antibody Type Recombinant mAb Application WB, IHC P, ICC, IP, ICFCM Reactivity Hu, Ms Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rabbit |
| Antigen | Stat6 |
| Synonyms | IL-4 Stat, Signal transducer and activator of transcription 6 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P42226 |
| Clone Number | SDT-337-32 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, IP, ICFCM |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:500 | |
| ICC | 1:250 | |
| ICFCM | 1:500 | |
| IP | 1:50 |
Background
Signal Transducer and Activator of Transcription 6 (STAT6), belonging to a family of seven similar members is primarily stimulated by interleukin(IL)-4 and IL-13, and acts as a T helper type 2 (Th2)-inducing factor. Thus, it is implicated in the pathophysiology of various allergic conditions, such as asthma, atopic dermatitis, eosinophilic esophagitis and food allergies, but also in tumor microenvironment regulation. Furthermore, certain forms of lymphomas, notably the Hodgkin lymphoma group, the primary mediastinal and primary central nervous system lymphoma, as well as some follicular and T cell lymphomas are associated with dysregulation of the STAT6 pathway [PMID: 33991851].
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