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Description
NA/LE Mouse anti-human CD28 mAbProduct Specification Host Mouse Antigen CD28 Synonyms TP44 Immunogen N A Accession P10747 Clone Number 15E8 Antibody Type Mouse mAb Isotype IgG1,k Isotype Control Invivo mouse IgG1 isotype control Application FCM, Functional Assay, in vitro T cell stimulation activation Reactivity Hu Purification Protein G Concentration Lot specific* (generally 0. 5 to 10 mg ml)* Endotoxin 1EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS
Product Specification
| Host | Mouse |
| Antigen | CD28 |
| Synonyms | TP44 |
| Immunogen | N/A |
| Accession | P10747 |
| Clone Number | 15E8 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | Invivo mouse IgG1 isotype control |
| Application | FCM, Functional Assay, in vitro T cell stimulation/activation |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | Lot specific* (generally 0.5 to 10 mg/ml)* |
| Endotoxin | ＜1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
|
Dilution
| application | dilution | species |
| Functional Assay | 1:500 | |
| FCM | 1:500-1000 |
Background
This antibody recognizes the same epitope as clone 15E8.
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular).
CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen-presenting cells (APCs). The CD86 expression on antigen-presenting cells is constitutive (expression is independent of environmental factors). It is generally reported, that CD28 is expressed on 50% of CD8+ T cells and more than 80% CD4+ T cells in human, but during the course of activation some T cells lose this molecule. In general, CD28 is a primary costimulatory molecule for T cell activation.
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