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Description
CNOT1 Recombinant Rabbit mAb (S-2273-65)Product Specification Host Rabbit Antigen CNOT1 Synonyms CCR4 NOT transcription complex subunit 1; CCR4 associated factor 1; Negative regulator of transcription subunit 1 homolog (NOT1H; hNOT1); CDC39; KIAA1007; NOT1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession A5YKK6 Clone Number S 2273 65 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms Positive Sample 293T, HeLa, Jurkat, NIH 3T3 Predicted
Product Specification
| Host | Rabbit |
| Antigen | CNOT1 |
| Synonyms | CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1; Negative regulator of transcription subunit 1 homolog (NOT1H; hNOT1); CDC39; KIAA1007; NOT1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | A5YKK6 |
| Clone Number | S-2273-65 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | 293T, HeLa, Jurkat, NIH/3T3 |
| Predicted Reactivity | Zf, Xe |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| ICC | 1:50 | Hu, Ms |
Background
CNOT1 (CCR4-NOT transcription complex subunit 1) is a crucial protein encoded by the CNOT1 gene and serves as the central scaffold for the CCR4-NOT complex, which is a master regulator of gene expression involved in mRNA deadenylation, transcriptional regulation, and protein ubiquitination. This complex plays a significant role in various cellular processes, including mRNA degradation, DNA repair, and circadian rhythm regulation. CNOT1 itself does not possess catalytic activity but is essential for maintaining the integrity of the CCR4-NOT complex and binding to other subunits and RNA-binding proteins. It is also implicated in neurodevelopmental disorders, as de novo variants in CNOT1 have been associated with intellectual disability, seizures, and other developmental issues.
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