SKU: 29645325599

Human CDKN2A/p16INK4a, His tag

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Description

Human CDKN2A/p16INK4a, His tagProduct Specification Species Human Synonyms Cyclin dependent kinase 4 inhibitor A (CDK4I), Multiple tumor suppressor 1 (MTS 1), p16 INK4a (p16 INK4; p16INK4A), CDKN2, MTS1 Accession P42771 Amino Acid Sequence Protein sequence (P42771, Met1 Asp156, with C 10*His) MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPDGGGGSHHHHHHHHHH Expression System

Product Specification


Species Human
Synonyms Cyclin-dependent kinase 4 inhibitor A (CDK4I), Multiple tumor suppressor 1 (MTS-1), p16-INK4a (p16-INK4; p16INK4A), CDKN2, MTS1
Accession P42771
Amino Acid Sequence

Protein sequence (P42771, Met1-Asp156, with C-10*His) MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPDGGGGSHHHHHHHHHH

Expression System E.coli
Molecular Weight Predicted MW: 18.2 kDa Observed MW: 18.2 kDa
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Tag with C-10*His
Physical Appearance Lyophilized Powder
Storage Buffer Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is ubiquitously expressed in many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53. Germline mutations of CDKN2A are associated with familial melanoma, glioblastoma and pancreatic cancer. The CDKN2A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

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Exchange/Return Notes
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SKU: 29645325599

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4.6 ★★★★★
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Chris Davis
Battle Creek, US
★★★★★ 5
I can use my remote again
Style: 1 to 1 IR Repeater
I added a center channel speaker, and it was partially blocking the remote sensor. This solution works like a charm and has an easy setup. One end points towards the existing IR, and the other end goes where you are going to point the remote to. The only suggestion is to include a USB connector with the product, so I don't need to find one.
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Reviewed in the United States on May 6, 2026
S
Verified Purchase
Stacy Moots
Port Orchard, US
★★★★★ 5
Very good signal repeater
Style: 1 to 1 IR Repeater
Fantastic product! I have a center channel for my surround sound that blocks the infrared sensor on my Sony Bravia TV that never works. I always have to get up to turn the TV on or off as well as other functions. So I purchased this product and it worked like a charm. Very simple to install, took less than 5 minutes . I didn’t have no compatibility issues. It was plugged play . Simply stick on the transmitting sensor by the receiving sensor on the TV and then the extended sensor for receiving from your remote control put where you would like it, lastly plug in the USB plug into any 5V power block and you’re done. Now I have no issues with range with controlling my TV, which is great.!👏🏼. Definitely a good product. I would highly recommend…
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Reviewed in the United States on November 10, 2025
P
Verified Purchase
Peter M. Klein
Carnegie, US
★★★★★ 5
Easy to Set up
Style: 1 to 1 IR Repeater
Works great. Have Sonos playbar mounted behind TV and it does not support eARC, only IR, for use with AppleTV remote. This solved problem.
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Reviewed in the United States on May 17, 2026
T
Verified Purchase
Tbilisi
Lexington, US
★★★★★ 5
Works just as advertised!
Style: 1 to 1 IR Repeater
Super east to set up. Haven't had any issues in our very long living room so it must work at around 25ft
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Reviewed in the United States on May 6, 2026
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alex
Port Orchard, US
★★★★★ 1
DOESNT WORK / REFUND ONLY WITH RETURN
Style: 1 to 1 IR Repeater
Does NOT work. DO—NOT—-BUY Does NOT have the parts in the instructions. ONLY WAY TO GET A REFUND IS TO TAKE IT TO A STORE AND PAY TO HAVE IT RETURNED UNLESS ITS A STAPLES. DO NOT BUY.
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Reviewed in the United States on May 5, 2026

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