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Description
CD209 His Tag Protein, HumanProduct Specification Species Human Synonyms CD209 antigendendritic cell specific intracellular adhesion molecules (ICAM) 3 grabbingnon integrin; CD209 molecule; CD209; CDSIGNHIV gpl20 binding protein; CLEC4L; CLEC4LC type lectin domain family 4 member L; DCSIGN; DC SIGN; DC SIGN1; DC SIGN1C type lectin domain family 4, member L; DC SIGNMGC129965; Dendritic cell specific ICAM 3 grabbing non integrin 1 Accession Q9NNX6 Amino Acid Sequence Gln59 Ala404,
Product Specification
| Species | Human |
| Synonyms | CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin; CD209 molecule; CD209; CDSIGNHIV gpl20-binding protein; CLEC4L; CLEC4LC-type lectin domain family 4 member L; DCSIGN; DC-SIGN; DC-SIGN1; DC-SIGN1C-type lectin domain family 4, member L; DC-SIGNMGC129965; Dendritic cell-specific ICAM-3-grabbing non-integrin 1 |
| Accession | Q9NNX6 |
| Amino Acid Sequence | Gln59-Ala404, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 44kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Liu, W. et al. (2004) J. Biol. Chem. 279:18748. 2.Curtis, B.M. et al. (1992) Proc. Natl. Acad. Sci. USA 89:8356. 3.Mummidi, S. et al. (2001) J. Biol. Chem. 276:33196. |
Background
Human Dendritic Cell-specific ICAM-3 Grabbing Non-integrin (DC-SIGN)/CD209 is a member of the C-type lectin family. The canonical DC-SIGN/CD209 isoform is a 46 kDa, 404 amino acid (aa) type II transmembrane protein. The extracellular region contains a Ca2+-dependent carbohydrate-binding lectin domain. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
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