SKU: 35080491790

Alexa Fluor® 700 Mouse Anti-Human CD33 Antibody (S-R472)

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Description

Alexa Fluor® 700 Mouse Anti-Human CD33 Antibody (S-R472)Product Specification Host Mouse Antigen CD33 Synonyms Myeloid cell surface antigen CD33; Sialic acid binding Ig like lectin 3 (Siglec 3); gp67; SIGLEC3 Location Cell membrane Accession P20138 Clone Number S R472 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 700 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin

Product Specification


Host Mouse
Antigen CD33
Synonyms Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3 (Siglec-3); gp67; SIGLEC3
Location Cell membrane
Accession P20138
Clone Number S-R472
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Alexa Fluor® 700
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD33, also known as Siglec-3, is a 67 kDa type-I transmembrane sialic-acid-binding immunoglobulin-like lectin composed of an N-terminal V-set Ig domain that mediates glycan recognition, a membrane-proximal C2-set Ig domain, and a cytoplasmic tail harboring two immunoreceptor tyrosine-based inhibitory motifs (ITIMs); upon ligation by α2,3- or α2,6-linked sialylated glycoproteins or the complement component C1q, Src-family kinases phosphorylate these ITIMs, recruiting the SH2-domain-containing phosphatases SHP-1 and SHP-2 that dephosphorylate downstream signaling molecules, thereby suppressing calcium flux, PI3K activity, and activation of myeloid cells including monocytes, macrophages, dendritic cells, microglia, and myeloid-derived suppressor cells, while also modulating NK-cell cytotoxicity and cytokine production; CD33 is highly expressed on committed myeloid progenitors and over-expressed on >90 % of acute myeloid leukemias, making it the target of the antibody–drug conjugate gemtuzumab ozogamicin, and alternative splicing generates a shorter isoform lacking the ligand-binding V domain that can still dampen immune responses; genetically, the rs3865444(C) allele that reduces CD33 surface expression is protective against late-onset Alzheimer’s disease because lower microglial CD33 lessens inhibition of Aβ phagocytosis, implicating the receptor in neurodegeneration as well as in infection, autoimmunity, and cancer immune evasion.

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SKU: 35080491790

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Jessica Smith
Houston, US
★★★★★ 5
Exactly what I was looking for
Size: King, Color: Bright White
It’s exactly what I was looking for. It fits well and makes the bed look more finished.
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Reviewed in the United States on May 25, 2026
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Jose Javier Garcia Fernandez
Carnegie, US
★★★★★ 3
Med Quality prod
Size: Full, Color: Light Grey
A little wrinkle
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Reviewed in the United States on April 25, 2026
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Armie Sheffield
Lowell, US
★★★★★ 5
Awesome product
Size: King, Color: Navy Blue
From this point forward, this is the only company that I would use. All is one color, and not having the white fabric in the middle is a bonus!
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Reviewed in the United States on May 14, 2026
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Cat
Lake Worth, US
★★★★★ 5
Bed pleated duster
Size: Full, Color: Beige
Lightweight great price easy to fit the bed
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Reviewed in the United States on April 16, 2026
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DMB
Port Orchard, US
★★★★★ 5
Nice dark blue color
Size: Twin, Color: Navy Blue
Bought 2 dark blue for twin beds and they look good with my blue and white quilts covering the beds. There are some wrinkles in the cloth due to packaging which may relax with time. but don't show much due to the dark color. I did find any defects in the stitching or fabric on the items I purchased. A note for prospective buyers is that the dust ruffle covers the entire bed foundation, so get help to put on under a heavy mattress.
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Reviewed in the United States on April 18, 2026

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