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Description
MUC18/CD146 His Tag Protein, HumanProduct Specification Species Human Synonyms METCAM, CD146, Melanoma cell adhesion molecule, MCAM, Cell surface glycoprotein MUC18, Gicerin, MUC18, MelCAM, HEMCAM Accession P43121 Amino Acid Sequence Val24 Gly559, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | METCAM, CD146, Melanoma cell adhesion molecule, MCAM, Cell surface glycoprotein MUC18, Gicerin, MUC18, MelCAM, HEMCAM |
| Accession | P43121 |
| Amino Acid Sequence | Val24-Gly559, with C-terminal 10*His VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 80-100kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Mills L. et al. (2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-5114. 2、Taira E. et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-387. 3、Fritzsche F R. et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-464. |
Background
CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis.
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4.3 ★★★★★
Based on 28 reviews
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Product Reviews
★★★★★ 4
Great product for sensitive skin
Style: Tolerance Control Soothing Skin Recovery Cream
I have sensitive skin that is constantly getting irritated by moisturizers/seemingly simple skin care products. I read a few blogs/articles/reviews on different products others have tried for similar issues and this one came up, so I decided to give it a try. It’s nice and light and goes on smoothly. Skin feels moisturized and does not get irritated, so that’s a win! The only reason I took off 1 star is it leaves my skin a bit oily for my liking, but that could just be my skin.
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Reviewed in the United States on February 9, 2026
★★★★★ 5
perfect for sensitive skin
Style: Tolerance Control Soothing Skin Recovery Cream
This provided perfect therapy for sensitive skin. IT WORKS!
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Reviewed in the United States on May 19, 2026
★★★★★ 5
LOVE
Style: Tolerance Control Soothing Skin Recovery Cream
I have extremely sensitive skin and this stuff is AMAZING. After being in sun, facial, stripped skin from treatments or products it’s super calming.
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Reviewed in the United States on May 10, 2026
★★★★★ 5
Beautiful Garden Statue
Style: 1 Pack - Angel with Lantern
This was a gift to my son’s family, and they loved it! They displayed it inside before Easter and loved the addition it made to their Easter celebration! Very nice item, loved by all.
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Reviewed in the United States on May 11, 2026
★★★★★ 5
A fun way to add a little light to my yard.
Style: 1 Pack - Dragon with Lantern
I hung it up on my outdoor storage shed and the grandkids love it. The color did fade from black to gray quickly, but it still looks nice. The light works almost all night and my yard is mostly partial shade so that amazing. I actually planned to paint it green anyway so I do have that advantage.
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Reviewed in the United States on May 5, 2026