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Description
IL-4R alpha/CD124 His Tag Protein, MouseProduct Specification Species Mouse Synonyms IL 4R alpha, CD124, IL4R, IL4RA Accession P16382 Amino Acid Sequence Ile26 Arg233, with C terminal 8*His IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRGGGSHHHHHHHH Expression System HEK293 Molecular Weight 35 45kDa Purity >95% by SDS PAGE Endotoxin
Product Specification
| Species | Mouse |
| Synonyms | IL-4R alpha, CD124, IL4R, IL4RA |
| Accession | P16382 |
| Amino Acid Sequence | Ile26-Arg233, with C-terminal 8*His IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHMEMNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNLYPSNNLLYKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPINILMSGVYYTARVRVRSQILTGTWSEWSPSITWYNHFQLPLIQRGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Nelms K. et al. (2003) The IL-4 receptor: signaling mechanisms and biologic functions. Annual Review of Immunology. 17: 701-738. |
Background
IL-4Rα is a member of the hematopoietin receptor superfamily. Among the defining features of the members of this superfamily of receptors are shared structural motifs in the extracellular region, which consists of type III fibronectin domains. These motifs include conserved paired Cys residues and, in the membrane proximal region, a WSXWS motif. The latter has been proposed to be required for maintaining the receptor in a conformation favorable to cytokine binding. Structural alterations in the IL-4Rα extracellular region may result in altered receptor signaling capabilities. Indeed, a variant of the human IL-4Rα chain containing a Ile50Val substitution was isolated from atopic individuals and has been shown to enhance signal transduction resulting in the increased production of IgE.
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4.3 ★★★★★
Based on 14 reviews
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Product Reviews
★★★★★ 3
Okay
I like that it fits my umbrella well, hinges open for easy application and removal, and that it has enough light for us to see our food at night.
I do not like that half of the outer lights do not work part of the time until I take out the batteries and swap them around.
Fine enough for the price, not worth the hassle of returning.
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Reviewed in the United States on May 10, 2025
★★★★★ 5
Perfect!
Lightweight and easy to use! Love the three light settings.
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Reviewed in the United States on April 27, 2026
★★★★★ 5
Easy to use.
Works well. Light is bright. Our new patio umbrella does not have e a center pole, so the lights get somewhat blocked. But still pretty useful.
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Reviewed in the United States on April 5, 2026
★★★★★ 5
Sturdy & easy to move around
Its solid & sturdy. It does exactly what it’s supposed to. You have the option to fill it up with water or sand , I choose water. It holds the umbrella in place. The wheels and handle make it really easy to move around, which is a huge plus. It fits perfectly and feels very well made. Great addition for my pool area!
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Reviewed in the United States on April 18, 2026
★★★★★ 5
Heavy-Duty Base with Convenient Mobility
This umbrella base does exactly what it’s supposed to—keeps the umbrella stable while still being easy to move around when needed. Once filled with water/sand, it feels solid and secure even on slightly windy days, which gives peace of mind.
The built-in wheels are a standout feature. Moving the base across the patio is smooth and doesn’t require much effort. The handle placement is well thought out, making repositioning quick and hassle-free.
Overall, it’s a great balance of stability and convenience. Highly recommend if you want a sturdy base without sacrificing mobility.
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Reviewed in the United States on March 31, 2026