SKU: 45296826053

LIN28A Rabbit Polyclonal Antibody

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Description

LIN28A Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen LIN28A Synonyms Protein lin 28 homolog A; Lin 28A; Zinc finger CCHC domain containing protein 1; CSDD1; LIN28; ZCCHC1 Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Endoplasmic reticulum Accession Q9H9Z2 Antibody Type Polyclonal antibody Isotype IgG Application WB Reactivity Hu, Ms Positive Sample T 47D, NCCIT, JAR, NTERA 2, F9 Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation

Product Specification


Host Rabbit
Antigen LIN28A
Synonyms Protein lin-28 homolog A; Lin-28A; Zinc finger CCHC domain-containing protein 1; CSDD1; LIN28; ZCCHC1
Immunogen Recombinant Protein
Location Cytoplasm, Nucleus, Endoplasmic reticulum
Accession Q9H9Z2
Antibody Type Polyclonal antibody
Isotype IgG
Application WB
Reactivity Hu, Ms
Positive Sample T-47D, NCCIT, JAR, NTERA-2, F9
Purification Immunogen Affinity
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:5000 Hu, Ms
IHC-P 1:500-1:1000 Hu, Ms

Background

LIN28A is an evolutionarily-conserved RNA-binding protein that harbors a cold-shock domain and two CCHC-type zinc knuckles, enabling it to dock onto specific motifs (e.g., UGAU loops) in mRNAs and micro-RNA precursors; by blocking the biogenesis of the tumor-suppressive let-7 family and by directly stabilizing or enhancing translation of metabolic, hypoxic and pluripotency transcripts (including HIF1α, IGF2BP3 and OCT4 targets), LIN28A sustains pluripotency, drives aerobic glycolysis, fosters embryonic and adult tissue regeneration, and when re-activated in cancers promotes stemness, angiogenesis, epithelial-to-mesenchymal transition, chemoresistance and poor patient prognosis.

Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
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SKU: 45296826053

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4.1 ★★★★★
Based on 8 reviews
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Product Reviews
S
Verified Purchase
Stacy H
Fort Morgan, US
★★★★★ 5
Must-Have for Active Dogs!
Style: Sport, Size: Large
The Chuckit Sport 26L Dog Ball Launcher has been a game-changer for my large dog! My 80-pound Labrador loves to play fetch, and this launcher makes it so much easier and more enjoyable for both of us. The 26” length gives me the leverage to throw the ball much farther than I could by hand, which really helps burn off my dog’s energy. The included large ball (3”) is the perfect size for big dogs, and I appreciate that it’s made from durable rubber, so it withstands a lot of chewing and rough play. What I really love is that the launcher is so lightweight and easy to use. I can play fetch with my dog for extended periods without my arm getting tired. The ergonomic handle also provides a comfortable grip, which is a nice touch. If you have a large, active dog, the Chuckit Sport 26L is a must-have. It’s well-made, durable, and makes fetch more fun for both you and your dog. Highly recommend!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 3, 2024
D
Verified Purchase
DD
Phoenix, US
★★★★★ 5
ChuckIt is AMAZING!
Style: Sport, Size: Large
I can't throw a ball to save my soul. Just got this today and lobbed a ball to the far end of my 1- acre yard. The dog loves it, and I love it!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 8, 2026
S
Verified Purchase
Sean
Carnegie, US
★★★★★ 4
I recommend using the KONG Extreme Dog Toy
Style: Sport, Size: Large
Helpful for throwing as much as my dog wants to fetch. I actually had to get a cortisone injection in my shoulder a few months after getting my dog - never had a dog with this much energy before! The Chuckit really helps. Downside: The ball that comes with it is larger than a tennis ball, so may be too much for smaller doge. I can't imagine my sister-in-law's french bulldog carrying it! Also, in our house it gets destroyed within minutes, as my dog is a strong chewer. For this situation, I recommend using the KONG Extreme Dog Toy, Black, size Large. This is shaped sort of like a snowman, which means it bounces unpredictably at times. My dog eventually chews the "head" off of this toy, but the remaining 2/3 still fits in the Chuckit (and is actually easier to throw with the "head" missing!). One caveat: the KONG is significantly heavier than the ball included with the Chuckit, so be aware of that... Also, we ordered our first Chickit in October 2015, then needed to replace it in May of 2017, as it broke. I think the plastic became brittle over that time, as we left it out in the sun & rain in Florida. Since it is cheap to replace, that's not a big deal. (We ordered three Kong toys over that same period of time!) To summarize, it's a very helpful tool to get the ball further, faster, with less strain, than without it. Knowing there are alternatives to the included ball for heavy chewers makes it worthwhile.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 19, 2017
D
Verified Purchase
DesertRoads
Whiting, US
★★★★★ 5
Great Ball Launcher!
Style: Sport, Size: Large
Our dogs love this ball launcher! I can throw the ball long distances without any arm strain. The balls wear out, and as described by others, tennis balls don’t fit. Buy extra balls if this is of concern. We bought a few of the “Chuck It” rubber 3” balls and they have worked well for our dogs. It’s a great value and fun for the dogs.
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Reviewed in the United States on March 28, 2025
C
Verified Purchase
Cheri Who
Alexandria, US
★★★★★ 5
Chuckit!! Just Chuck it!!
Style: Sport, Size: Large
Chuck it further than your skinny little arms can chuck it. Doggo loved this, I loved this and when we were done Doggo promptly hid it under the porch so I couldn’t take it from him. It’s not a squeaky toy, it’s for fetch. You wing it out toward the yard and it flies, bounces if it’s lucky then is attacked in an adoring manner. We like it!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2026

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