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Description
PAX5 Recombinant Rat mAb (S-R200)Product Specification Host Rat Antigen PAX5 Synonyms Paired box protein Pax 5, B cell specific transcription factor (BSAP), PAX 5, PAX 5 Location Nucleus Accession Q02548 Clone Number S R200 Antibody Type Rat mAb Isotype IgG2a Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rat |
| Antigen | PAX5 |
| Synonyms | Paired box protein Pax-5, B-cell-specific transcription factor (BSAP), PAX-5, PAX 5 |
| Location | Nucleus |
| Accession | Q02548 |
| Clone Number | S-R200 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:1000-1:4000 | null |
| ICC | 1:500 | null |
Background
The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage 'inappropriate' genes and simultaneously activating B lineage–specific genes. This transcriptional reprogramming restricts the broad signaling capacity of uncommitted progenitors to the B cell pathway, regulates cell adhesion and migration, induces VH-DJH recombination, facilitates (pre-)B cell receptor signaling and promotes development to the mature B cell stage. Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role for Pax5 in controlling the identity and function of B cells throughout B lymphopoiesis. PAX5 has also been implicated in human B cell malignancies, as it is deregulated by chromosomal translocations in a subset of acute lymphoblastic leukemias and non-Hodgkin lymphomas.
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