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Description
Human CD105, His tagProduct Specification Species Human Synonyms Endoglin, ENG, END Accession P17813 Amino Acid Sequence Protein sequence(P17813, Glu26 Gly586, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Endoglin, ENG, END |
| Accession | P17813 |
| Amino Acid Sequence | Protein sequence(P17813, Glu26-Gly586, with C-10*His) ETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:62.4kDa Actual:85kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | with C-10*His |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1. It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of cancer cells to other locations in the body. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia (HHT) type 1. HHT is actually the first human disease linked to the TGF beta receptor complex. This condition leads to frequent nose bleeds, telangiectases on skin and mucosa and may cause arteriovenous malformations in different organs including brain, lung, and liver.
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4.2 ★★★★★
Based on 17 reviews
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Product Reviews
★★★★★ 5
Great value and fun for dogs!
Color: 4 PCS Ocean Series
These squeaky dog toys are a great buy! The pack comes with a nice variety, and each toy keeps my dog entertained for hours. They are colorful, lightweight, and the squeakers work well without being too loud. The material feels durable so far, even with regular chewing. Perfect for small to medium dogs. Definitely worth the price—would buy again!
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Reviewed in the United States on March 27, 2026
★★★★★ 5
Love these toys!
Color: 4 PCS Ocean Series
My 1 year old pup loves these toys. The clam has been a big hit since it crinkles, has a squeaker "pearl" and a rope. He very proudly brings me this to play with him. Recommend!
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Reviewed in the United States on May 17, 2026
★★★★★ 4
Stitching can be weakened by continuous aggressive play.
Color: 4 PCS Ocean Series
Not as tough as touted. I will say that my dog loves the textures and sounds. Safely watching so that it does not shred when toy is ripped. Size was perfect for my 80lb dog. Pet has throughly enjoyed an enjoys the toys.
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Reviewed in the United States on April 1, 2026
★★★★★ 5
Tough toys for Chewers
Color: 4 PCS Ocean Series
My dogs love these toys, they are tough on toys so these appear to be well made. I don't expect them to stay in one piece but if they can last more than a week, they are perfect. So far, they have lasted three weeks so this is a record for toys. Cute, and funny to watch pups play with them. Squeaks once in awhile and really cool toys.
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Reviewed in the United States on September 10, 2025
★★★★★ 2
Not for aggressive chewers
Color: 1 PCS Salmon
My gsd puppy really liked it but within a few days it started fraying and the strings would get stuck in her mouth. Not for aggressive chewers and not durable.
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Reviewed in the United States on May 5, 2026