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Description
Biotinylated VEGF-R2/KDR Avi&His Tag Protein, HumanProduct Specification Species Human Synonyms VEGF R2, KDR, CD309, FlK1, Fetal liver kinase 1, vascular endothelial growth factor receptor 2 Accession P35968 Amino Acid Sequence Ala20 Glu764, with C terminal Avi & 10*His Tag
Product Specification
| Species | Human |
| Synonyms | VEGF-R2, KDR, CD309, FlK1, Fetal liver kinase 1, vascular endothelial growth factor receptor 2 |
| Accession | P35968 |
| Amino Acid Sequence | Ala20-Glu764, with C- terminal Avi & 10*His Tag ASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEGGGSGGGSGLNDIFEAQKIEWHEHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 110-140kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Huusko J. et al. (2010) The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice. Cardiovascular Research. 86(1): 122-130. |
Background
Vascular endothelial cell growth factor (VEGF) and VEGF receptor 2 (VEGF-R2) are closely related to angiogenesis in glioma. A number of phosphorylated sites, such as Y801, Y951, Y1175, and Y1214 in the VEGF-R2 intracellular domains mediate critical signal transductions, including PI3K/AKT, MAPK, and PKC pathways. Main functions of VEGF-R2 include increasing the expression of VEGF and inducing tumor angiogenesis. In addition, VEGF plays a role in promoting vascular endothelial cell division and angiogenesis through VEGF-R2 and is also involved in promoting the aggressive growth of tumors. In the kidney, VEGF is almost exclusively expressed in glomerular and tubular epithelial cells, while the VEGF-R2 is mainly present in glomerular and tubular endothelial cells, as well as in interstitial cells. The present study shows that VEGF-R2 overexpression in advanced thyroid cancer maintains cancer malignancy and cell survival. Thus, selective targeting of VEGFR2/KDR signaling may be a potential strategy for advanced thyroid cancer treatment.
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4.0 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 5
Very good
The best quality. Runs like new again.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 12, 2026
★★★★★ 1
garbage spark plugs
misfired after 30 minutes of driving cylinder 4 misfire code, left me stranded on the highway with baby in car. “(9621)” at the end of description is a lie, was not compatible with my vehicle even with compatibility test.
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Reviewed in the United States on May 17, 2026
★★★★★ 5
Actually works on BMW!
I purchased this after the shorter black fluted tool I bought last year failed me. This thing is way better constructed, fits perfect , and actually works to turn it after you can’t turn it by hand any further. Was able to get torqued down to 25nm no problem finally with ease!
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Reviewed in the United States on November 12, 2024
★★★★★ 5
Works great
Works great
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Reviewed in the United States on May 26, 2025
★★★★★ 5
Great product
Fits the whole filter cover all the way...and the metal is great quality
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Reviewed in the United States on May 26, 2025
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