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Description
Alexa Fluor® 488 Mouse Anti-Human CD66b Antibody (S-3042)Product Specification Host Mouse Antigen CD66b Synonyms Cell adhesion molecule CEACAM8; CD67 antigen; Carcinoembryonic antigen CGM6; Carcinoembryonic antigen related cell adhesion molecule 8 (CEA cell adhesion molecule 8Imported); Non specific cross reacting antigen NCA 95; CGM6; CEACAM8 Location Cell membrane Accession P31997 Clone Number S 3042 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human Peripheral
Product Specification
| Host | Mouse |
| Antigen | CD66b |
| Synonyms | Cell adhesion molecule CEACAM8; CD67 antigen; Carcinoembryonic antigen CGM6; Carcinoembryonic antigen-related cell adhesion molecule 8 (CEA cell adhesion molecule 8Imported); Non-specific cross-reacting antigen NCA-95; CGM6; CEACAM8 |
| Location | Cell membrane |
| Accession | P31997 |
| Clone Number | S-3042 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood leukocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD66b, also known as CEACAM8, is a cell surface glycoprotein and a member of the immunoglobulin superfamily, specifically the carcinoembryonic antigen (CEA)-like subfamily. It is a glycosylphosphatidylinositol (GPI)-anchored protein with a molecular weight of approximately 95-100 kDa. CD66b is primarily expressed on granulocytes, including neutrophils and eosinophils, and plays a significant role in cell adhesion in a calcium-independent manner. It mediates heterophilic adhesion with other CEA-related cell adhesion molecules, such as CD66c, and is particularly involved in the activation and adhesion of neutrophils. Additionally, CD66b has been implicated in various biological processes, including the regulation of eosinophil activation and the immune response in allergic diseases and parasitic infections. In cancer research, CD66b expression has been associated with prognosis in non-small cell lung cancer, with higher levels in the immune stroma linked to poorer outcomes.
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