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Description
HPV18 E7 Recombinant Rabbit mAb (SDT-1413-107)Product Specification Host Rabbit Antigen HPV18 E7 Synonyms Protein E7; E7 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession P06788 Clone Number SDT 1413 107 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution,
Product Specification
| Host | Rabbit |
| Antigen | HPV18 E7 |
| Synonyms | Protein E7; E7 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | P06788 |
| Clone Number | SDT-1413-107 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Background
HPV18 E7 is a ~100-amino-acid, zinc-binding, dimeric oncoprotein encoded early in the HPV18 life cycle; via its conserved CR1/CR2 motifs it binds the retinoblastoma tumor suppressor pRb and related pocket proteins, displacing E2F transcription factors and forcing the infected epithelial cell into S-phase, while additional interactions with APC/C-Cdh1, p21Cip1 and p27Kip1 override checkpoint control, promote centrosome duplication errors and genomic instability, and together with its C-terminal CXXC motifs that coordinate Zn2+ for dimerization, ensure sustained proliferation and the oncogenic progression that underlies the majority of HPV18-driven cervical and other anogenital cancers.
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