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Description
SLC40A1/Ferroportin Recombinant Rabbit mAb (S-2172-35)Product Specification Host Rabbit Antigen SLC40A1 Ferroportin Synonyms Ferroportin; Ferroportin 1; Iron regulated transporter 1; Solute carrier family 40 member 1Imported; FPN; FPN1; IREG1; SLC11A3 Immunogen Synthetic Peptide Location Cell membrane Accession Q9NP59 Clone Number S 2172 35 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample Caco 2, T 47D, mouse spleen, mouse liver, rat spleen
Product Specification
| Host | Rabbit |
| Antigen | SLC40A1/Ferroportin |
| Synonyms | Ferroportin; Ferroportin-1; Iron-regulated transporter 1; Solute carrier family 40 member 1Imported; FPN; FPN1; IREG1; SLC11A3 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q9NP59 |
| Clone Number | S-2172-35 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Caco-2, T-47D, mouse spleen, mouse liver, rat spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
SLC40A1, also known as Ferroportin, is a crucial iron exporter protein that plays a vital role in iron homeostasis. It is primarily located in the plasma membrane of cells involved in iron metabolism, such as enterocytes, hepatocytes, and macrophages. In enterocytes, Ferroportin facilitates the transport of iron absorbed from the diet into the bloodstream. In hepatocytes and macrophages, it helps in the release of stored iron for systemic use. This protein contains multiple transmembrane domains and functions by moving iron ions from the intracellular space to the extracellular environment. Mutations in the SLC40A1 gene can lead to conditions like hemochromatosis, where iron overload occurs due to impaired iron export. Its regulation is also influenced by hepcidin, a hormone that binds to Ferroportin and induces its internalization and degradation, thereby controlling iron release from cells.
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