SKU: 651620845

KRAS Recombinant Rabbit mAb (S-443-69)

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Description

KRAS Recombinant Rabbit mAb (S-443-69)Product Specification Host Rabbit Antigen KRAS Synonyms GTPase KRas, K Ras 2, Ki Ras, c K ras, c Ki ras, KRAS2, RASK2 Immunogen Recombinant Protein Location Cytoplasm, Cell membrane Accession P01116 Clone Number S 443 69 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0.

Product Specification


Host Rabbit
Antigen KRAS
Synonyms GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, KRAS2, RASK2
Immunogen Recombinant Protein
Location Cytoplasm, Cell membrane
Accession P01116
Clone Number S-443-69
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu, Ms, Rt
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 null
IHC-P 1:250 null

Background

The K-Ras protein is a GTPase, a class of enzymes which convert the nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). In this way the K-Ras protein acts like a switch that is turned on and off by the GTP and GDP molecules. Like other members of the ras subfamily of GTPases, the K-Ras protein is an early player in many signal transduction pathways. K-Ras is usually tethered to cell membranes because of the presence of an isoprene group on its C-terminus. KRAS acts as a molecular on/off switch, using protein dynamics. Once it is allosterically activated, it recruits and activates proteins necessary for the propagation of growth factors, as well as other cell signaling receptors like c-Raf and PI 3-kinase.

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Exchange/Return Notes
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SKU: 651620845

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