SKU: 69144307732

SHBG His Tag Protein, Human

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Ships within 48 hours · Estimated delivery Sep 27 - Oct 2

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Description

SHBG His Tag Protein, HumanProduct Specification Species Human Accession P04278 Amino Acid Sequence Leu30 His402, with C His tag Expression System HEK293 Molecular Weight Predicted MW: 42. 2 kDa Observed MW: 50 kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer 0. 2M PBS, pH7. 4. Reconstitution Reconstitute no more than 1 mg mL according to the size in deionized water after rapid

Product Specification


Species Human
Accession P04278
Amino Acid Sequence

Leu30-His402, with C-His tag
Expression System HEK293
Molecular Weight

Predicted MW: 42.2 kDa Observed MW: 50 kDa
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

0.2M PBS, pH7.4.
Reconstitution

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage


12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to androgens and estrogens. SHBG is found in all vertebrates apart from birds. SHBG inhibits the function of these hormones. Thus, the local bioavailability of sex hormones is influenced by the level of SHBG. SHBG’s production is regulated under the influence of FSH on Sertoli cells, enhanced by insulin, retinol, and testosterone. The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) > testosterone > androstenediol > estradiol > estrone. SHBG levels are usually about twice as high in women than in men. In women, SHBG serves to limit exposure to both androgens and estrogens. Low SHBG levels in women have been associated with hyperandrogenism and endometrial cancer due to heightened exposure to androgens and estrogens, respectively. During pregnancy, due to activation of SHBG production in the liver by high estrogen levels, SHBG levels increase by five-fold to ten-fold.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 69144307732

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4.7 ★★★★★
Based on 5 reviews
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Product Reviews
S
Verified Purchase
Susan Says
Phoenix, US
★★★★★ 5
Your high-energy dog will love it!
Why did I wait so long to get one of these?!? I am the stereotypical throws-like-a-girl person, and my dog really needs to have an option that forces her to run far and fast. This is it. I can get that ball half a soccer field away at a minimum if I want. The ball is super bouncy, which adds an element of fun to her attempts to tame it and bring it back. Super worth the money (which wasn't much!). I've never had one of these before, so can't compare to the non-folding version. This one is easy to carry and fits in a drawer for storrage. No way you can fit it in a pocket, especially if you have a phone in one and dog treats in the other.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 14, 2026
L
Verified Purchase
Leo
Waukegan, US
★★★★★ 5
Great usability
I prefer this version over the non-foldable stick, as this one I can fit into my bag and carry it out easily. Great size and has a locking feature to prevent it from folding up when throwing. Highly recommend, my dogs love fetch and it is hard to chew if they get their hands on it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 13, 2025
J
Verified Purchase
Jennifer L Kasanke
Chelsea, US
★★★★★ 5
Holds up! Good thrower!
Good quality! Throws far! Love this brand!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 10, 2026
M
Verified Purchase
Michael
Battle Creek, US
★★★★★ 4
Almost Perfect
If you’ve ever seen these things, the foldable ones are just as good as the standard ones. I just wish when you folded it up there was a way to lock it into that position. When you unfold it to play, you lock it into place with the orange locking slide so it doesn’t fold up on you. But when you’re done playing and fold it up, there’s no way to lock it into that position, it can keep unfolding if you carry it around with you, plus the orange locking slide keeps sliding up and down. It’s not a huge deal, but they could’ve made it better.
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Reviewed in the United States on April 29, 2026
S
Verified Purchase
SC
Omaha, US
★★★★★ 5
Helpful
I’ve used Chuckit ball launchers, this one is foldable, great for my back pack when camping with my dog
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 27, 2026

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