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Description
IL-17A Protein, HumanProduct Specification Species Human Synonyms Interleukin 17A; IL 17; IL 17A; Cytotoxic T Lymphocyte Associated Antigen 8; CTLA 8; IL17A; CTLA8; IL17 Accession Q16552 Amino Acid Sequence Gly24 Ala154 with a N terminal Met Expression System E. coli Molecular Weight Approximately 31. 0 kDa, a homodimer of two 132 amino acid polypeptide chains. Purity 95% by SDS PAGE or HPLC. Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer
Product Specification
| Species | Human |
| Synonyms | Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17 |
| Accession | Q16552 |
| Amino Acid Sequence | Gly24-Ala154 with a N-terminal Met |
| Expression System | E.coli |
| Molecular Weight | Approximately 31.0 kDa, a homodimer of two 132 amino acid polypeptide chains. |
| Purity | ＞95% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20 mM PB, with 150 mM NaCl, pH 7.4. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 132 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Human Interleukin-17A (IL-17A) is encoded by the IL17A gene located on the chromosome 6 and belongs to the IL-17 family that contains IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The six known members of this family are secreted as homodimers. Human IL-17 exhibits 63% amino acid identity with mouse IL-17，IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Human IL-17A is a 31.0kDa, disulfide-linked homodimer of two 132 amino acid polypeptide chains.
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