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Description
PCSK9 His Tag Protein, MouseProduct Specification Species Mouse Synonyms PCSK9, FH3, PC9, FHCL3 Accession Q80W65 Amino Acid Sequence Gln35 Gln694, with C terminal 10* His Tag
Product Specification
| Species | Mouse |
| Synonyms | PCSK9, FH3, PC9, FHCL3 |
| Accession | Q80W65 |
| Amino Acid Sequence | Gln35-Gln694, with C-terminal 10* His Tag QDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIHFSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIHNTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVYASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVARVHDTARADRTSGEATVAAAICCRSRPSAKASWVQGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 60-68kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Jaén R I. et al. (2022) Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release. Int J Mol Sci. 23(16): 9114. |
Background
PCSK9 (proprotein convertase subtilisin-kexin type 9) is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. PCSK9 undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism.
Atherosclerosis is a cardiovascular disease caused mainly by dyslipidemia and is characterized by the formation of an atheroma plaque and chronic inflammation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that induces the degradation of the LDL receptor (LDLR), which contributes to increased levels of LDL cholesterol and the progress of atherosclerosis.
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4.7 ★★★★★
Based on 26 reviews
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Product Reviews
★★★★★ 5
Fit my 23 CRV hybrid does the job
Fit my 23 CRV hybrid does the job
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 2, 2026
★★★★★ 5
Fits on 2026 Honda CRV Hybrid Touring Sport
Both items fit perfectly in my 2026 Honda CRV Hybrid Touring Sport
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Reviewed in the United States on February 22, 2026
★★★★★ 5
Definitely will buy again!
Perfect Fit for Honda Accord 2024 hybrid Touring
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Reviewed in the United States on January 25, 2026
★★★★★ 5
Fit 2025 Honda crv hybrid sport l
These fit my 2025 Honda crv hybrid sport-l perfectly. They are much more economical than having the shop replace them. I wish it said what the composition is- cotton or otherwise, because I have read you should oil cotton filters to work as intended. I didn't oil them amd so far haven't had any problems, but time will tell.
They are a great value for the money and work as described. I would recommend these if you want to save some money on parts and labor for replacing your air filters. There are some good videos online that show you how step by step.
I haven't noticed any odors or lack of durability since installing them.
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Reviewed in the United States on April 3, 2026
★★★★★ 5
Good replacement for oem
Size: CRV 2023-26 2.0L Hybird
Fits my 2024 crv hybrid
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Reviewed in the United States on May 30, 2026