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Description
Mouse Anti-Human Aiolos Antibody (S-3264)Product Specification Host Mouse Antigen Aiolos Synonyms Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3 Location Cytoplasm, Nucleus Accession Q9UKT9 Clone Number S 3264 Antibody Type Mouse mAb Isotype IgG1,k Application ICFCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months
Product Specification
| Host | Mouse |
| Antigen | Aiolos |
| Synonyms | Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3 |
| Location | Cytoplasm, Nucleus |
| Accession | Q9UKT9 |
| Clone Number | S-3264 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:200 | Hu |
Background
Aiolos (encoded by IKZF3) is a zinc-finger transcription factor of the Ikaros family that is indispensable for lymphocyte biology. By recruiting chromatin-remodeling complexes to its target genes, it enforces quiescence in mature B cells, orchestrates immunoglobulin receptor editing, and cooperates with other Ikaros members to direct late-stage B-cell maturation. Its deletion or inactivating mutations unleash malignant transcriptional programs, making Aiolos a key tumor suppressor whose loss underpins B-cell acute lymphoblastic leukemia and multiple myeloma.
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