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Description
Alexa Fluor® 488 Mouse Anti-Human CD303 Antibody (S-R662)Product Specification Host Mouse Antigen CD303 Synonyms C type lectin domain family 4 member C; Blood dendritic cell antigen 2 (BDCA 2); C type lectin superfamily member 7; Dendritic lectin; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; CLEC4C Location Cell membrane Accession Q8WTT0 Clone Number S R662 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation
Product Specification
| Host | Mouse |
| Antigen | CD303 |
| Synonyms | C-type lectin domain family 4 member C; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin superfamily member 7; Dendritic lectin; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; CLEC4C |
| Location | Cell membrane |
| Accession | Q8WTT0 |
| Clone Number | S-R662 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD303, also known as Blood Dendritic Cell Antigen 2 (BDCA-2), is a C-type lectin receptor encoded by the CLEC4C gene, selectively expressed on human plasmacytoid dendritic cells (pDCs); it couples via the ITAM‐containing FcεRIγ adaptor to trigger Syk/Ca²⁺ signaling that drives endocytosis, the secretion of large amounts of type I interferon and pro-inflammatory cytokines, and the down-regulation of the pDC interferon response, making it both a key sentinel of viral RNA/DNA and a potential therapeutic target in autoimmunity and allergy.
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