SKU: 80896662970

SIRP-α Fc Chimera Protein, Human

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Description

SIRP-α Fc Chimera Protein, HumanProduct Specification Species Human Synonyms SIRP Fc Chimera protein ; BIT, BITbrain immunoglobulin like molecule with tyrosine based activation motifs, Brain Ig like molecule with tyrosine based activation motifs, CD172 antigen like family member A, CD172a antigen, CD172a, Inhibitory receptor SHPS 1, Macrophage fusion receptor, MFR, MFRtyrosine phosphatase SHP substrate 1, MyD 1 antigen, MYD1, MYD 1, P84, protein tyrosine phosphatase, non receptor

Product Specification


Species Human
Synonyms SIRP-α Fc Chimera protein ;BIT, BITbrain-immunoglobulin-like molecule with tyrosine-based activation motifs, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a antigen, CD172a, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MFR, MFRtyrosine phosphatase SHP substrate 1, MyD-1 antigen, MYD1, MYD-1, P84, protein tyrosine phosphatase, non-receptor type substrate 1, PTPNS1, SHP substrate 1, SHPS1, SHPS-1, SHPS1CD172A, signal-regulatory protein alpha, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, SIRP alpha, SIRPA, SIRPalpha, Sirp-alpha-1, SIRPalpha2, Sirp-alpha-2, Sirp-alpha-3, SIRPtyrosine-protein phosphatase non-receptor type substrate 1
Accession P78324
Amino Acid Sequence

Glu31-Arg370, with C-terminal Human IgG1 Fc

Expression System HEK293
Molecular Weight

70~80 kDa(Reducing)

Purity >95%, by SDS-PAGE under reducing conditions
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.2, 5% trehalose

Reconstitution

Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Background

Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.

Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
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SKU: 80896662970

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Cathlin McDonnell
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I rely on bed baths for staying clean, due to severe physical disability. This product is a mainstay in my grooming routine. I use it on my face and all over my body. It is very gentle and provides moisturization, as well. The scent is quite subtle, and does not bother my chemical sensitivities.
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Reviewed in the United States on May 21, 2026
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Linda G. Hill
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Scent: Lavender, Size: 12 Fl Oz (Pack of 1)
Great toner,leaves my skin glowing,removes residual dirt,moisturizing.
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Reviewed in the United States on April 30, 2026
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Skylar Daniels
Charlottesville, US
★★★★★ 5
MY NEW FAVE
i am obsessed with this moisturizer: the price is affordable and it works beautifully. it's like a lightweight serum compared to thick moisturizers. it has clean ingredients, no fragrance, and leaves my skin feeling so soft with no greasiness
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Reviewed in the United States on March 31, 2026
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Jewelbee
Whiting, US
★★★★★ 5
I’m enjoying it!
I’ve really been enjoying this moisturizer so far. It feels lightweight, comfortable, and absorbs nicely into the skin without feeling greasy or heavy. I also love that it is fragrance free. My skin feels hydrated throughout the day, and it layers well with the rest of my skincare products. I also use the matching face wash and toner from this line, and together I’ve been very happy with the overall results. My skin has been looking smoother, healthier, and more balanced since incorporating these products into my routine. One important thing to note is that this moisturizer does not contain SPF or sun protection, so make sure to apply a separate sunscreen during the day if that’s important for your skincare routine. Overall, I think this is a great everyday moisturizer and I’ll continue using it.
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Reviewed in the United States on May 26, 2026
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Luna
San Leandro, US
★★★★★ 5
Lightweight moisturizer, worth it.
Love it! Its lightweight and silky. Makes my skin feel hydrated and smooth. I apply after cleansing my face..can't say if it actually provides 80hr moisture. So far so good. Would repurchase.
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Reviewed in the United States on May 3, 2026

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