SKU: 82158309929

CD27/TNFRSF7 His Tag Protein, Human

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Description

CD27/TNFRSF7 His Tag Protein, HumanProduct Specification Species Human Synonyms Cluster of differentiation 27 Accession P26842 Amino Acid Sequence Thr21 Ile192, with C terminal 8*His TPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRIGGGSHHHHHHHH Expression System HEK293 Molecular Weight 35 50kDa (Reducing) Purity 95% by SDS PAGE&RP HPLC Endotoxin <0. 1EU g

Product Specification


Species Human
Synonyms Cluster of differentiation 27
Accession P26842
Amino Acid Sequence

Thr21-Ile192, with C-terminal 8*His TPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRIGGGSHHHHHHHH
Expression System HEK293
Molecular Weight 35-50kDa (Reducing)
Purity

＞95% by SDS-PAGE&RP-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Background

Cluster of differentiation 27 (CD27) is a member of the tumour necrosis factor receptor superfamily and plays a key role in T-cell activation by providing a costimulatory signal. Bound to its natural ligand CD70, CD27 signalling enhances T-cell proliferation and differentiation to effector and memory T cells and therefore has potential as an immune modulatory target in cancer treatment. The CD27 agonistic antibody varlilumab showed promising efficacy in haematological as well as solid cancers. Current studies investigate the combination of the CD27 agonistic antibody varlilumab in combination with the PD1 axis targeting immune checkpoint inhibitors like nivolumab or atezolizumab. Further, CD70 expression is used as a therapeutic target for ADCs, antibodies inducing ADCC, as well as the immunological target for chimeric antigen receptor gene-modified T cells and specific dendritic cell vaccination. In line with this, targeting the CD27 axis was shown to be feasible and safe in early clinical trials with the most commonly occurring side effects being thrombocytopenia, fatigue and nausea.

Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
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  • To process your return/exchange, please contact us at [email protected]
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SKU: 82158309929

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4.7 ★★★★★
Based on 9 reviews
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Product Reviews
K
Verified Purchase
Kimberly Frost
Omaha, US
★★★★★ 5
Great value extra storage
Size: 42inch Tall (NOT included wood planks), Color: Black, Size: 42inch Tall (NOT included wood planks), Color: Black
This was a Great storage option for a corner where we had no cabinets, it has very stylish hardware Storage Space it’s quality built it fits well it’s very easy to install. It came with screws. All the hardware, I’m going to put white dishes on the shelves with my coffee bar.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 8, 2025
A
Verified Purchase
Anonymous
Battle Creek, US
★★★★★ 5
Quality pipes for a good price
Size: 42inch Tall (NOT included wood planks), Color: Black
This item is just as described. It is the pipe fitting portion of a 3 shelf unit. You must buy your shelving separately once the rails have been installed. Purchasing the pieces this way was much more cost-effective than separately buying each part from the hardware store, and all the pieces were clean and ready to be mounted unlike the pieces from the hardware store. It was moderately difficult to hang, since you are trying to keep everything very level. I imagine the distance between each rail will be a factor in how easy this is to level. The difficulty may have also stemmed from the fact that we were mounting it in a small toilet room and had little room to maneuver during the installation process. Still, it is a good product and we are considering purchasing a second one for another location in our home.
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Reviewed in the United States on April 6, 2019
B
Verified Purchase
B. Billy
Lowell, US
★★★★★ 4
Not real Black Iron, but works just as well
Size: 42inch Tall (NOT included wood planks), Color: Black
First, these parts that I got were not real Black Iron pipes like you would pick up at a hardware store, they are like furniture grade tubes for an IKEA shelving system. The thread would fit 3/4 pipe from like HD, but they are not the same, I know this because I just bought some of the pipe and parts for a small shelf right before ordering this. I should have known from the price, the real stuff is kind of pricey, but nicer. The elbows and T-connectors as well as the flanges seem more like galvanized steel painted black. HOWEVER, the end product is pretty nice and very versatile as to where you would want to put it. It is still pretty sturdy, and if screwed into a stud, I believe it would hold a lot of weight. The entire shelving system is painted black, so unlike Black Iron, it will not stain your hands black when handling it. Putting this together took about 30 min, the longest part was adjusting angles and lengths to get it flat and squared, but was not hard at all. This kit does NOT come with shelf boards, so length of that is up to you. It also came with mounting screws, but they are thin and I would suggest as your getting boards for shelves, also pick up some beefier screws, U used #12 - 1 1/4" wood screws with the sleeves for drywall and a little longer for securing it into a stud. All in all, this black pipe shelf looks nice, is nice and will work out great, just know, it is not the real Black Iron pipes and parts you would get from a hardware store, but the threads would fit if you wanted to add to this. I only knocked down one star because of this, and if I am going to buy more of these, I would prefer the real stuff and not go with this one.
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Reviewed in the United States on June 5, 2020
K
Verified Purchase
Kristin Miller
Bozeman, US
★★★★★ 5
Love these!!!
Size: 42inch Tall (NOT included wood planks), Color: Black
Super sturdy..looks excellent. Industrial and clean lines....lots of space for our kids bathroom. The wood does not come with it but was easy to get lowes. We actually added another shelf on the top bracket to make 4 shelves. They're nice and wide to fit baskets and organize things. For teenagers bathroom! My husband installed by himself and he isn't the handiest of guys but it it wasn't bad. I do recommend getting pipe fastners to secure the boards to the pipes so they don't shift around
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Reviewed in the United States on June 2, 2021
S
Verified Purchase
S. Meunier
Boise, US
★★★★★ 5
Nice pipe shelves! Excellent quality!
Size: 28inch Tall (NOT included wood planks), Color: Black
I really like the fact that the pieces were already painted. I compared the cost of the unit to buying the pieces from the big box store and this was far more cost effective for me. The installation went well and I ended up creating a template for installation. For the template, I measured the width of one of the flanges (part that mounts to the wall), cut a piece of material the same width. I found the center and drew a line down the middle. I then placed the section with top and bottom holes over the center line and then marked the other two holes. I then drilled out the holes, put on wall and used level to plumb. I used small pilot drill bit to drill through the template into the wall. One thing to note is that I did not use the included anchors instead opting for some from the big box store.
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Reviewed in the United States on March 29, 2020

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