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Description
Human ABP1/AOC1 Protein, His TagProduct Specification Species Human Synonyms Diamine oxidase [copper containing], Amiloride binding protein, Amiloride binding protein 1, Amine oxidase copper domain containing protein 1, Histaminase, Kidney amine oxidase (KAO; KDAO), ABP, DAO Accession P19801 Amino Acid Sequence Protein sequence (P19801, Glu20 Val751, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Diamine oxidase [copper-containing], Amiloride-binding protein, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase (KAO; KDAO), ABP, DAO |
| Accession | P19801 |
| Amino Acid Sequence | Protein sequence (P19801, Glu20-Val751, with C-His Tag) EPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLPGPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 85.1 kDa Observed MW: 95 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
AOC1, or Amine Oxidase Copper Containing 1, is a key enzyme in histamine and polyamine metabolism. Primarily expressed in the intestine, placenta, and kidney, it catalyzes the degradation of histamine and oxidative deamination of polyamines like putrescine. This function is crucial for regulating local histamine levels, thereby influencing inflammatory and immune responses. AOC1 also plays a significant role in intestinal barrier function and mucosal protection. Its activity impacts various physiological and pathological processes, including allergies, asthma, and inflammatory bowel disease. Furthermore, AOC1 is a target for certain anti-inflammatory drugs, highlighting its therapeutic relevance. Genetic variations in AOC1 can affect enzyme activity and individual susceptibility to related disorders.
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